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Murdering senescence? Careful with that axe!


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... the "axe" being senolytics ...

The Sheekey Science Show YT channel posted this video a little over a year ago ...


Senescent cells accumulate with age. Studies have shown that removing senescent cells can alleviate symptoms of aging. However, a recent study has put this into question...
Grosse et al., Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan, Cell Metabolism
(2020), https://doi.org/10.1016/j.cmet.2020.0...
Xu, M., Pirtskhalava, T., Farr, J.N. et al. Senolytics improve physical function and increase lifespan in old age. Nat Med 24, 1246–1256 (2018). https://doi.org/10.1038/s41591-018-00...
Baker, D., Wijshake, T., Tchkonia, T. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011). https://doi.org/10.1038/nature10600


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