corybroo Posted October 18, 2021 Report Share Posted October 18, 2021 U of Wisconsin-Madison reports a new study Fasting is required to see the full benefit of calorie restriction in mice Some highlights: The researchers discovered that, combined with eating less, fasting reduces frailty in old age and extends the lifespan of mice. And fasting alone can improve blood sugar and liver metabolism. Surprisingly, mice that ate fewer calories but never fasted died younger than mice that ate as much as they wanted, suggesting that calorie restriction alone may be harmful. … previous studies had unintentionally combined calorie restrictions with long fasts by providing animals with food just once a day. It was difficult, then, to distinguish the effects of one from the other. To untangle these factors, Lamming's group designed four different diets for mice to follow. One group ate as much as they wanted whenever they wanted. Another group ate a full amount, but in a short period of time—this gave them a long daily fast without reducing calories. The other two groups were given about 30% fewer calories either once a day or dispersed over the entire day. It turned out that many of the benefits originally ascribed to calorie restriction alone—better blood sugar control, healthier use of fat for energy, protection from frailty in old age and longer lifespans—all required fasting as well. Mice who ate fewer calories without fasting didn't see these positive changes. Fasting on its own, without reducing the amount of food eaten, was just as powerful as calorie restriction with fasting. Fasting alone was enough to improve insulin sensitivity and to reprogram metabolism to focus more on using fats as a source of energy. The livers of fasting mice also showed the hallmarks of healthier metabolism. The researchers did not study the effect of fasting alone on lifespan or frailty as mice aged, but other studies have suggested that fasting can provide these benefits as well. "We need to know whether this fasting is required for people to see benefits," Lamming says. "If fasting is the main driver of health, we should be studying drugs or diet interventions that mimic fasting rather than those that mimic fewer calories." Quote Link to comment Share on other sites More sharing options...
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