Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice In this study, we reevaluated the effect of the genotype and sex of recombinant inbred strains of mice on their response to dietary restriction

[Matt]

Quote

 

"Of the eight groups of mice (female and male mice of four RI lines) studied, we were able to replicate the observation of only one of the eight results previously reported by Liao et al. (2010).

"We did observe that DR significantly reduced the lifespan of male 98-RI mice; however, this decrease (2% for median lifespan) was very small compared with the report by Liao et al. (2010), who observed over a 40% decrease in mean lifespan."

"In summary, our study was to a large extend unable to replicate the effect of DR on the lifespan of the four RI lines reported by Liao et al. (2010); therefore, the lifespan data in their study should be considered suspect because of the limited number of mice used to measure lifespan."

 

Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice In this study, we reevaluated the effect of the genotype and sex of recombinant inbred strains of mice on their response to dietary restriction

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13500?

I've remained quite optimistic and continued a more serious level of CR despite some of the earlier findings like from Liao et al, and the rhesus monkey studies. It's pretty common that studies come to very different results for various reasons. And we as humans just have a lot better control over what we're doing and can change things in response to CR and its effects on our health.

[Matt]

Two very different results from each study:

"Liao et al. (2010) reported DR to have the greatest negative effect on the lifespan of male and female mice, 115-RI mice, for example, DR (40%) reduced the mean survival of female and male 115-RI mice ~85% and ~70%"

"DR had a much greater effect on the lifespan of the female 115-RI mice than male mice, for example, median survival was increased 50% for female mice compared with only 9% for males. DR (40%) also significantly increased both the median and mean survival of the female 115-RI mice; however, the increase in the median or mean survival of the male 115-RI mice was not statistically significant. The 90th percentile survival was increased by 35% and 12% for female and male mice, respectively, fed 40% DR."