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Curious about BMI on CR


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On 3/11/2022 at 9:14 AM, Alex2022 said:

  I am considering starting CR.

What makes you think you aren't already CR'ed? 

Your BMI is fine, lower BMI than yours is associated with shorter, not longer, lifespan in humans. See: http://www.bmj.com/content/353/bmj.i2156.abstract

If you want to try something different, I'd go with brown fat activation. 

Edited by Gordo
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What was your weight prior to starting your plant based diet? Your calorie intake now?

Do you have signs of doing CR like low body temperature, lowering fT3 and fT4? 

Lower BMI range on a healthy diet is associated with the lowest all cause mortality



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I also recommend you watch the above Fontana video. If you click through to YouTube and look at the video description or comments you will find a clickable index of highlights (Luigi took my comment and added it to to video description which in turn segmented the actual video on YouTube). 

13:44 Talks about calorie restriction studies in primates

25:30 talks about CALERIE study in humans

29:02 specifically mentions the CR Society and shows a before/after pic and biomarkers of one member

36:55 talks about the importance of increasing adiponectin and especially the importance of reduced core body temperature as a biomarker for longevity

38:00 skeletal muscle profile on CR, importance of downregulation of IGF-1

43:40 Side effects of chronic severe CR - how to know if you are overdoing CR

44:30 It is NOT TRUE that the more CR the better. Talks about study showing how 40% CR did not result in increased longevity for 2/3rds of the subtypes of mice tested. 20% CR is optimal for many strains of mice.  Biomarkers are key for determining what the optimal CR level is.   You must have sufficient energy to promote longevity.

46:15 Used to think it was just about the calories, but now we know that is NOT true.  Composition of diet is important, meal timing is important - CR with eating all day does not result in longevity in mice (50:00)

51:10 Discusses ongoing human intermittent fasting clinical trial

53:40 Importance of low protein / methionine restriction for longevity independent of CR (blocks tumor development)

59:25 You should eat around 10% protein ("a calorie is not a calorie", "stay away from low carb or ketogenic diets")

1:04:20 Talks about the gut microbiome.  Diet reliably and rapidly changes the gut microbiome, protein intake and fiber are key, the more diversity of vegetables you eat the better your gut microbiome, which results in reduced inflamation (related to short chain fatty acids). Eat legumes, whole grains, and lots of vegetables.

1:10:50 Your gut microbiome impacts your physiologic response to CR

1:13:00 Describes other pieces of the health/longevity puzzle he will talk about in a future lecture: exercise, breathing and rate of respiration, sleep, meditation, phytochemicals, cognitive training

1:18:00 Future of medicine is prevention.  Reducing mental stress, reducing sedentary lifestyle, reducing excessive calorie intake, and eliminating poor diets are key.

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  • 3 months later...

Just a first look, quick impression, which is pretty interesting though. In the presence of optimal lifestyle parameters (3 or 4 as described by Li in the referred article) BMI, except when it is very high, has negligible relevance. The lifestyle parameters score is on the contrary pretty relevant



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