Clinton Posted March 13 Report Share Posted March 13 In 2016 they reversed aging in cells using the yamanaka factors. Now it sounds like they’ve been able to reverse aging in an entire organism https://www.futuretimeline.net/blog/2022/03/10-anti-aging-mice.htm Quote Link to comment Share on other sites More sharing options...
AlanPater Posted March 13 Report Share Posted March 13 53 minutes ago, Clinton said: In 2016 they reversed aging in cells using the yamanaka factors. Now it sounds like they’ve been able to reverse aging in an entire organism https://www.futuretimeline.net/blog/2022/03/10-anti-aging-mice.htm They did not show the animals lived longer. Quote Link to comment Share on other sites More sharing options...
Clinton Posted March 14 Author Report Share Posted March 14 I’m not able to read the entire paper on Nature, but they don’t discuss lifespan. They do say that the yamanaka factors applied in-vivo were able to reverse epigenetic clocks in skin and kidney. Reading the abstract the author’s describe true age reversal- assuming that epigenetic clocks are a true reflection of age. Quote Link to comment Share on other sites More sharing options...
Ron Put Posted March 16 Report Share Posted March 16 The mice lived 30% longer: "Encouraged by this result, the team used the same short reprogramming method during cyclic periods in live mice with progeria. The results were striking: Compared to untreated mice, the reprogrammed mice looked younger; their cardiovascular and other organ function improved and—most surprising of all—they lived 30 percent longer, yet did not develop cancer. On a cellular level, the animals showed the recovery of molecular aging hallmarks that are affected not only in progeria, but also in normal aging."https://www.salk.edu/news-release/turning-back-time-salk-scientists-reverse-signs-aging/ Quote Link to comment Share on other sites More sharing options...
Saul Posted March 17 Report Share Posted March 17 Progeria mice are hardly a good choice; they're the opposite of the sort of creatures that you need to make a useful study. They're mice with a mutation that drastically shortens lifespan. -- Saul Quote Link to comment Share on other sites More sharing options...
Clinton Posted March 23 Author Report Share Posted March 23 So using the same Yamanaka factors - but only 3 of the 4 (or 5); Sinclair explains it once again here, AND he says that THEY ARE TRYING THIS RIGHT NOW in non-human primate trials. This is the real deal - instructing all tissues that they are a different age. Biotracking, Age Reversal & Other Advanced Health Technologies (lifespanpodcast.com) Any issues using this link?? Thanks Quote Link to comment Share on other sites More sharing options...
Saul Posted March 23 Report Share Posted March 23 We'll all live forever. 🙂 -- Saul Quote Link to comment Share on other sites More sharing options...
Clinton Posted March 24 Author Report Share Posted March 24 lol well - this treatment of factors is the closest thing I've seen regarding an anti-aging 'treatment'. No doubt it has limitations and is still a ways from being available, but exciting still Quote Link to comment Share on other sites More sharing options...
AlanPater Posted October 28 Report Share Posted October 28 How scientists want to make you young again Research labs are pursuing technology to “reprogram” aging bodies back to youth. By Antonio Regalado October 25, 2022https://www.technologyreview.com/2022/10/25/1061644/how-to-be-young-again/?utm_source=pocket-newtab Quote Link to comment Share on other sites More sharing options...
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