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Caloric Restriction - latest human data


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Caloric Restriction - latest human data

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Calorie restriction (CR) is the chronic reduction of total calorie intake without malnutrition and this can range from 20-40%. CR has been shown in many different model organisms to extend lifespan and these effects appear to get more modest the closer the species is to humans. But, how effective is it in humans and are there any safety consequences? Well, in this video I take a look at some recent data published from the CALERIE trial, a 2-year study where human patients underwent on average a 14% CR. In particular they focus on immune system aging such as the thymus and identify the gene PLAG2G7 as an interesting target to follow-up.

 

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One good thing from the video is a tightening up of the definition of CR. The use of the term CHRONIC is effective. That term, if/when taken seriously -- i.e., not acute-- discounts: yo-yo and popular tv, "magazine" or bestseller "diets". May even dispel some of the fasting hype.

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