Mike41 Posted July 6, 2022 Report Share Posted July 6, 2022 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061380/ Quote Link to comment Share on other sites More sharing options...
Dean Pomerleau Posted July 7, 2022 Report Share Posted July 7, 2022 Recent? The meta-analysis you point to [1] is from 2014. Recent randomized control trials of vitamin D supplements haven't found significant benefits in subjects who weren't deficient in vitamin D to start with [2]. --Dean ----- [1] Schöttker B, Jorde R, Peasey A, Thorand B, Jansen EH, Groot Ld, Streppel M, Gardiner J, Ordóñez-Mena JM, Perna L, Wilsgaard T, Rathmann W, Feskens E, Kampman E, Siganos G, Njølstad I, Mathiesen EB, Kubínová R, Pająk A, Topor-Madry R, Tamosiunas A, Hughes M, Kee F, Bobak M, Trichopoulou A, Boffetta P, Brenner H; Consortium on Health and Ageing: Network of Cohorts in Europe and the United States. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ. 2014 Jun 17;348:g3656. doi: 10.1136/bmj.g3656. PMID: 24938302; PMCID: PMC4061380. [2] 1. Nutrients. 2022 Jan 12;14(2):303. doi: 10.3390/nu14020303. Critical Appraisal of Large Vitamin D Randomized Controlled Trials. Pilz S(1), Trummer C(1), Theiler-Schwetz V(1), Grübler MR(1), Verheyen ND(2), Odler B(3), Karras SN(4), Zittermann A(5), März W(6)(7)(8). As a consequence of epidemiological studies showing significant associations of vitamin D deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular diseases, cancer, and mortality, large vitamin D randomized controlled trials (RCTs) have been designed and conducted over the last few years. The vast majority of these trials did not restrict their study populations to individuals with vitamin D deficiency, and some even allowed moderate vitamin D supplementation in the placebo groups. In these RCTs, there were no significant effects on the primary outcomes, including cancer, cardiovascular events, and mortality, but explorative outcome analyses and meta-analyses revealed indications for potential benefits such as reductions in cancer mortality or acute respiratory infections. Importantly, data from RCTs with relatively high doses of vitamin D supplementation did, by the vast majority, not show significant safety issues, except for trials in critically or severely ill patients or in those using very high intermittent vitamin D doses. The recent large vitamin D RCTs did not challenge the beneficial effects of vitamin D regarding rickets and osteomalacia, that therefore continue to provide the scientific basis for nutritional vitamin D guidelines and recommendations. There remains a great need to evaluate the effects of vitamin D treatment in populations with vitamin D deficiency or certain characteristics suggesting a high sensitivity to treatment. Outcomes and limitations of recently published large vitamin D RCTs must inform the design of future vitamin D or nutrition trials that should use more personalized approaches. DOI: 10.3390/nu14020303 PMCID: PMC8778517 PMID: 35057483 [Indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Saul Posted July 7, 2022 Report Share Posted July 7, 2022 9 hours ago, Dean Pomerleau said: but explorative outcome analyses and meta-analyses revealed indications for potential benefits such as reductions in cancer mortality or acute respiratory infections. Importantly, data from RCTs with relatively high doses of vitamin D supplementation did, by the vast majority, not show significant safety issues, except for trials in critically or severely ill patients or in those using very high intermittent vitamin D doses. The recent large vitamin D RCTs did not challenge the beneficial effects of vitamin D regarding rickets and osteomalacia, that therefore continue to provide the scientific basis for nutritional vitamin D guidelines and recommendations. -- Saul Quote Link to comment Share on other sites More sharing options...
Ron Put Posted September 5, 2022 Report Share Posted September 5, 2022 I think I've posted this before, but now I am reevaluating my supplementation with vitamin D based on it: Low levels of vitamin D are also linked to longevity: Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study See also this:https://www.snpedia.com/index.php/rs2060793 Quote Link to comment Share on other sites More sharing options...
mccoy Posted September 7, 2022 Report Share Posted September 7, 2022 I've reported this a while ago: my levels of vitamin D3, measured after a summer of daily exposure to natural UV rays (sunrays at hours around noon), was 32 ng/ml (I hope the units are right). The body did not produce more, even if it plausibly had the possibility. At first I was disappointed. But afterwards, I reasoned, perhaps that indicates that higher concentrations were not optimal for me? Quote Link to comment Share on other sites More sharing options...
corybroo Posted September 7, 2022 Report Share Posted September 7, 2022 1 hour ago, mccoy said: At first I was disappointed. But afterwards, I reasoned, perhaps that indicates that higher concentrations were not optimal for me? Quite reasonable, I think. The same is true for carrots and vitamin A. Is it possible to get an overdose of vitamin A from eating carrots? If you do want to overdose, use supplements. Hypervitaminosis A Quote Link to comment Share on other sites More sharing options...
Mike41 Posted September 7, 2022 Author Report Share Posted September 7, 2022 4 hours ago, mccoy said: I've reported this a while ago: my levels of vitamin D3, measured after a summer of daily exposure to natural UV rays (sunrays at hours around noon), was 32 ng/ml (I hope the units are right). The body did not produce more, even if it plausibly had the possibility. At first I was disappointed. But afterwards, I reasoned, perhaps that indicates that higher concentrations were not optimal for me? Interesting I had the same experience several years ago and my levels were in the same range as yours. But where I live it’s not possible 6 months out of the year and so I supplement 1000 mg from late October until March. A test in February showed I maintained the summer levels doing that Quote Link to comment Share on other sites More sharing options...
Ron Put Posted October 9, 2022 Report Share Posted October 9, 2022 This might give a clue as to some of the correlations often sited. It makes sense to me at first listen: Quote Link to comment Share on other sites More sharing options...
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