Bioreactor-Grown Mitochondria for Potential Anti-Aging

[BrianA]

These upcoming papers should be interesting reads:

 

"Today, Mitrix Bio announced early results of an 18-month project which involved top experts and contractors from the University of Connecticut Technology Incubation Program, Stanford University, Université Laval Quebec, and Nova Southeastern University. A series of mitochondrial transplants were performed in brain, eye, liver, immune system, and skin tests. In these tests, “young” highly functional mitochondria are grown in prototype bioreactors and transfused into the bloodstream. Cells absorb them to help supplement old, dysfunctional mitochondria and reverse energetic decline. These tests showed apparent age reversal in multiple endpoints in animal disease models in-vivo and human cells in-vitro. The results indicate potential future therapies for diseases such as Alzheimer’s, macular degeneration, cardiovascular disease, frailty, and immune senescence. A series of peer-reviewed papers will be released in coming months.

Experiments not only point toward specific diseases but suggest anti-aging effects on test animals’ strength, cognition, and appearance.

“These are still early results, and more work remains to be done in human tests, but we think the data points to a potential breakthrough in longevity…in a shorter timeframe compared to other longevity treatments,” says CEO Tom Benson."

 

https://www.lifespan.io/news/bioreactor-grown-mitochondria-for-potential-anti-aging/

[Saul]

Interesting.

  --  Saul

[Saul]

15 hours ago, BrianA said:

These upcoming papers should be interesting reads:

 

"Today, Mitrix Bio announced early results of an 18-month project which involved top experts and contractors from the University of Connecticut Technology Incubation Program, Stanford University, Université Laval Quebec, and Nova Southeastern University. A series of mitochondrial transplants were performed in brain, eye, liver, immune system, and skin tests. In these tests, “young” highly functional mitochondria are grown in prototype bioreactors and transfused into the bloodstream. Cells absorb them to help supplement old, dysfunctional mitochondria and reverse energetic decline. These tests showed apparent age reversal in multiple endpoints in animal disease models in-vivo and human cells in-vitro. The results indicate potential future therapies for diseases such as Alzheimer’s, macular degeneration, cardiovascular disease, frailty, and immune senescence. A series of peer-reviewed papers will be released in coming months.

Experiments not only point toward specific diseases but suggest anti-aging effects on test animals’ strength, cognition, and appearance.

“These are still early results, and more work remains to be done in human tests, but we think the data points to a potential breakthrough in longevity…in a shorter timeframe compared to other longevity treatments,” says CEO Tom Benson."

 

https://www.lifespan.io/news/bioreactor-grown-mitochondria-for-potential-anti-aging/

Hi again, Brian!

I've read the Link -- and the Mitrix project is extremely interesting.  The Lifespan.io summary of course leaves out much; but the article claims that there will be a string of peer reviewed papers.

The set of academic institutions is impressive -- this isn't something studied by person in his/her basement.  It's fascinating that the researchers have devised machines that are capable of -- and have -- multiply "young" mitochondria.

Something like this that works for animals, usually works for people -- and, according to the article, the technique has been successfully applied in vivo to animals (and in vitro to human cells), with impressive results.

I'm also impressed by the fact that coatings are applied to the mitochondria, specific to help prevent them from being attacked by the recipient's immune system; and that the coatings applied are also specific to which organs are being targeted for anti-aging.

The expected peer reviewed papers will (hopefully) validate the results.

Thanks for posting this,

  --  Saul

[BrianA]

I hope if this succeeds eventually they can release a more general form of it, to just rejuvenate all the mitochondria everywhere in the body. Having to pay for an take like 10+ different versions of this, each targeted to a single organ seems kinda ridiculous.

[IgorF]

IMHO rejuvenation of the host ones is the way to go, having something that could be attacked by the host immune system when the things will go wrong (and they definitely will in many unpredictability situations due to extreme complexity of the chemical networks of the cells and intracellular areas) is too fragile(

[BrianA]

Here's a video from Mitrix from the Ending Age-Related Diseases 2022 conference. I still haven't seen the promised papers.