corybroo Posted August 1, 2022 Report Share Posted August 1, 2022 A study that almost sounds too good to be true. Molecule may prevent age-related diseases and increase life expectancy and wellness A new study led by Professors Einav Gross and Shmuel Ben-Sasson of the Faculty of Medicine at the Hebrew University of Jerusalem (HU) has identified a group of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function. Gross said, "Mitochondria, the cell's 'power plants,' are responsible for energy production. ... Although these 'batteries' wear out constantly, our cells have a sophisticated mechanism that removes defective mitochondria and replaces them with new ones." However, this mechanism declines with age, leading to cell dysfunction and deterioration in tissue activity. The study also showed that these molecules can be used preventively. "In the future, we hope we will be able to significantly delay the development of many age-related diseases and improve people's quality of life," said Ben-Sasson. Further, these compounds are user-friendly and can be taken orally. I found the abstract of the base paper a little more informative. Distinct designer diamines promote mitophagy, and thereby enhance healthspan in C. elegans and protect human cells against oxidative damage Impaired mitophagy is a primary pathogenic event underlying diverse aging-associated diseases such as Alzheimer and Parkinson diseases and sarcopenia. Therefore, augmentation of mitophagy, the process by which defective mitochondria are removed, then replaced by new ones, is an emerging strategy for preventing the evolvement of multiple morbidities in the elderly population. Based on the scaffold of spermidine (Spd), a known mitophagy-promoting agent, we designed and tested a family of structurally related compounds. A prototypic member, 1,8-diaminooctane (VL-004), exceeds Spd in its ability to induce mitophagy and protect against oxidative stress. VL-004 activity is mediated by canonical aging genes and promotes lifespan and healthspan in C. elegans. Moreover, it enhances mitophagy and protects against oxidative injury in rodent and human cells. [Emphasis added] Initial structural characterization suggests simple rules for the design of compounds with improved bioactivity, opening the way for a new generation of agents with a potential to promote healthy aging. Quote Link to comment Share on other sites More sharing options...
Saul Posted August 2, 2022 Report Share Posted August 2, 2022 Bioreactor-Grown Mitochondria for Potential Anti-Aging BrianA posted a topic in General Health and Longevity ... Mitrix Bio announced early results of an 18-month project which involved top experts and contractors from the University of Connecticut Technology Incubation Program, Stanford University, Université Laval Quebec, and Nova Southeastern University. A series of mitochondrial transplants were performed... July 19 4 replies Quote Link to comment Share on other sites More sharing options...
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