mccoy Posted August 13, 2022 Report Share Posted August 13, 2022 This is an interesting topic, since sometimes it occurs the necessity to be fully awake, in lack of, or notwithstanding sufficient sleep time. I've been listening to podcasts (for example, Pete Attia's the drive) where the effect of caffeine has been related to it's properties to bind to the adenosine receptors, adenosine being a neurotransmitter linked to the homeostatic sleep drive. In a few words, caffeine is an antagonist of adenosine. It binds to adenosine receptors, effectively counteracting, according to its concentration, the effect of sleep-inducing adenosine where such receptors are blocked. But, as I realized, the above explanation is not complete. The final result is actually related to an increased dopamine flow thru the following effect (source: Stahl's essential psychofarmacology). In a few words, adenosine can heterodimerize D2 receptors, reducing the affinity of D2 receptors for dopamine, hence blocking 'by proxy' the flow of this neurotransmitter. Quote Link to comment Share on other sites More sharing options...
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