mccoy Posted September 13, 2022 Report Share Posted September 13, 2022 I remember that in the past there have been some discussions about this psychedelic compound. Since I'm in the process of reading one of the main treaties of psychopharmacology (Stahl's essential psychopharmacology, 2021 5th edition) it has been interesting to come across this substance and to read about the mechanisms of action. Psilocybin is rapidly metabolized to psilocin, so they are both present after ingestion. Their hallucinogenic effect is mainly linked to agonism at the 5HT2A receptor, one of the main serotonin receptors. Agonism means that the psilocybin/psilocin molecule binds to the 5HT2A receptors, mimicking a powerful surge of natural serotonin, causing n amplified electric signal at some neural circuits. The anti-depressive drugs like the SSRIs also cause a greater flow of serotonin (by inhibiting its reuptake), so it is no wonder that psilocybin is being studied, as a breakthrough drug, as an antidepressant, anxiolytic and against PTSD. The mechanism of action of psilocybin, causing psychosis, hallucinations, and other experiences have been described as follows. It is all related to the strong stimulation of 5HT2A receptors in glutamatergic neurons in some areas of the brain. Please note that auditory hallucinations are more typical of schizophrenia and The serotoninergic hypothesis constitutes one of the hypotheses of psychosis; in the context of psilocybin most probably governs the amplified glutamate release in the visual cortex, which apparently is the root cause of all the visions occuring to the users of such substance. Quote Link to comment Share on other sites More sharing options...
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