Sildenafil (Viagra) associated with a 69% reduced risk of Alzheimer’s disease

[BrianA]

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

https://www.nature.com/articles/s43587-021-00138-z

PDF: https://www.nature.com/articles/s43587-021-00138-z.epdf?sharing_token=h6_SVnZgozQqqaStilLq6dRgN0jAjWel9jnR3ZoTv0MZlAf7NnNJckPwPyFGV_fXoOOl2YvQCRDmjrBvs5FCZGM7eGZHxaTtMG2asbfQvGbIIp2wQnKruEd17emNhyjAQv2qVTjASyBDcWcv9IYoz2jgc7hVZG2NWsbKtIPY7Oe3vTWKOsQQ5iVS7k7W2iHLAXngj6UY2NWJe_zeb65U8lV5gg0Fn_FJA0WngSuNlFo%3D&tracking_referrer=boingboing.net

Edited December 13, 2022 by BrianA

[Todd Allen]

Here's another study that found it has metabolic benefits in overweight men:

Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults

[BrianA]

Apparently it also helps with cardiovascular risks and overall risk of death:

 

Men with erectile dysfunction who take Viagra are 25% less likely to suffer an early death than those who don't, study suggests

https://www.dailymail.co.uk/health/article-11649627/Viagra-users-25-likely-suffer-early-death.html

[Saul]

Hi Brian!

I found your post to be very interesting.  I don't have erectile dysfunction, but I do have hypertension; I take lisinopril and Lasix for the condition.

However, the article that you posted noted that sildenafil causes a relaxing in smooth muscle tissue, resulting in dilation of blood vessels; one side effect of this is improved circulation is peripheral areas.

I have reduced circulation in my extremities -- especially hands.  I almost always have "cold hands", especially in winter.  Fortunately, I actually have several sildenafil pills (never used), 100mg, that I had long ago bisected into twice as many 50mg pills.  I contacted my nephrologist, describing the circumstances; he agreed that, dropping one Lasix pill and replacing it with a 50mg sildenafil pill, was worth trying.

It handled BP beautifully, and greatly reduced my "cold hands" problem.  So my nephrologist issued a prescription for a 90 day supply; but insurance will only supply 18 pills (instead of 90) for the 90 day supply.

I declined, and I'm looking for a SAFE source, at a reasonable price, for 50mg sildenafil pills.

There are many on-line sources the claim to sell the pills very reasonably -- but, I don't know which on-line supplier can be counted on to be supplying what I ordered.

I'm nearly sure that many members on these Forums can answer this question.  (I can obtain a prescription to whichever SAFE source from my nephrologist.)

Thanks,

  --  Saul

 

 

[BrianA]

Interesting, well glad to hear it helped with the blood pressure issue. I've heard Mark Cuban opened a pharmacy specifically to offer low cost generics, his site says a 30 pack of 50 mg is only $5.40 ? Take a look:

 

https://costplusdrugs.com/medications/sildenafilcitrate-20mg-tablet/

[Saul]

Thanks Brian!

I've created an account at Mark Cuban's Drug company.  50mg sildenafil is extremely cheap on his site.  To order any drug requiring a prescription, the site requires that you contact your doctor, and request the doctor to submit the prescription (the site won't contact your physician for you, in order to keep prices low).  So, I happily contacted my physician.

I'll report when as process continues.

(BTW, all drugs are quite cheap -- I can get most of my other meds at better prices at Cuban's site.)

  --  Saul

 

[Ron Put]

On 2/8/2023 at 6:48 AM, BrianA said:

Interesting, well glad to hear it helped with the blood pressure issue. I've heard Mark Cuban opened a pharmacy specifically to offer low cost generics, his site says a 30 pack of 50 mg is only $5.40 ? Take a look:

 

https://costplusdrugs.com/medications/sildenafilcitrate-20mg-tablet/

This is w seriously useful post, Brian! Thanks!

I just checked my dog's medications and the price difference is staggering!

My hat off to Cuban for doing this.

[Alex K Chen]

What about those who already have low blood pressure?

[Saul]

On 2/7/2023 at 9:30 PM, Saul said:

Thanks Brian!

I've created an account at Mark Cuban's Drug company.  50mg sildenafil is extremely cheap on his site.  To order any drug requiring a prescription, the site requires that you contact your doctor, and request the doctor to submit the prescription (the site won't contact your physician for you, in order to keep prices low).  So, I happily contacted my physician.

I'll report when as process continues.

(BTW, all drugs are quite cheap -- I can get most of my other meds at better prices at Cuban's site.)

  --  Saul

 

Hi again Brian!

I've created an account at Mark Cuban's site.  Unfortunately, I can't get any of my three physicians to send a prescription (for sildenafil, 50mg, 90 pills) for me to Cuban's site.  (They haven't said absolutely no; but it might take months for one of them to hopefully approve sending a prescription to Cuban's site.  My nephrologist did send that prescription, to be filled by my usual medical insurance, but the insurer only sent 18 pills, not 90.)

Possibly there is a physician or nurse practitioner reading on these Forums who would be kind enough to send such a prescription to Cuban's site?

Many thanks in advance,

  --  Saul

 

 

My hope:  There's a physician on this website who would be kind enough to send such a prescription