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Exogeneous ketones to decrease glucose/appetite and induce ketosis?

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Eric Verdin of Buck Institute is creating his own form of esters via juvlabs.com


All ketone drinks lowered blood glucose, free fatty acid and triglyceride concentrations, and had similar effects on blood electrolytes, which remained normal. In the final study, participants were given KE over 9 h as three drinks (n = 12) or a continuous nasogastric infusion (n = 4) to maintain blood D-βHB concentrations greater than 1 mM. Both drinks and infusions gave identical D-βHB AUC of 1.3–1.4 moles.min






A Ketone Ester Drink Lowers Human Ghrelin and Appetite

October 05, 2017

Many diets fail due to the inability to reduce food intake caused by increased hunger which is driven in large part, by hormones including the “hunger hormone” ghrelin. Ghrelin stimulates hunger and feeding in response to restricted food intake. Ketogenic diets (KD) are a promising strategy for weight loss, which may be caused by the effect of ketone bodies, including Beta-Hydroxybutyrate (β-HB), on hunger hormones. Consuming a ketone ester drink (KE) containing β-HB rapidly elevated blood ketones and reduced the desire to eat and perceived hunger by 50% for up to 4 hours. Elevated β-HB corresponded to significantly reduced levels of ghrelin 2-4 hours after consumption of KE. These findings point to a direct role of β-HB in the suppression of hunger associated with KD, and support the use of KE containing β-HB as a strategy to reduce hunger and aid weight loss during prolonged fasting or caloric restriction.



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  • InquilineKea changed the title to Exogeneous ketones to decrease glucose/appetite and induce ketosis?

2022 study


A relatively large body of work has demonstrated that ketone esters similar to BH-BD can reduce blood glucose response when taken before either a 75 g oral glucose bolus (20,21) or a mixed meal containing ∼84 g of carbohydrate (22, 40). In this study, consumption of BH-BD 30 min after a standard meal did not alter blood glucose responses compared to a non-ketogenic control beverage. The 30-min time interval was chosen to allow the carbohydrate from the study meal to blunt endogenous ketone production. It is possible that ketones must be consumed in advance of, or more closely in conjunction with dietary carbohydrate in order to modulate glycaemic response. It is also notable that the amount of carbohydrate in the standard meal used here (24 g) was low in comparison to previous studies, suggesting the effect of exogenous ketones on glycaemic response may only become detectable with greater carbohydrate load

Esters reduce it by 13mg/dl, which is quite decent!!


Figure 2. Concentrations of plasma non-esterified fatty acids, triacylglycerol, glucose, and insulin following equimolar ketone ester and ketone salt drinks, at two amounts, in subjects (n = 15) at rest. Values are means ± SEM. (A) Plasma FFA. (B) Plasma TG. (C) Plasma glucose. (D) Plasma insulin at baseline and after 30 and 60 min. EH, ketone ester high; EL, ketone ester low; SH, ketone salt high; SL, ketone salt low. *p < 0.05 difference from baseline value.

Edited by InquilineKea
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