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Cannabidiol/cannabinoids/weed/cannabis/marijuana and longevity/autophagy/beta-amyloid clearance?

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Cannabinoids and autophagy - some papers, but need to find a GOOD ONE



Does anyone try the edibles for the benefits of cannabinoids?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743431/ *glymphatic system, not much detail or insight*

I have some oral tinctures but they do make me very slightly psychedelic


There are studies comparing cannabis users and other users, but they're all ruined by the fact that most smoke it, and most don't use them responsibly (I don't even enjoy cannabis but I use it once in a while b/c I just KNOW the antioxidant/autophagy stuff all too well now)

CBD and aging:https://www.sciencedirect.com/science/article/pii/S075333222300865X




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  • InquilineKea changed the title to CBD/cannabinoids/weed/cannabis/marijuana and longevity/autophagy/beta-amyloid clearance?


Administration of low doses of THC in rats was associated with enhanced neurogenesis in the brain, especially in the hippocampus, and an improvement of cognitive functions. The administration of ultralow doses of THC in mice protected the brain from LPS neuroinflammation-induced cognitive damage [69]. THC was effective in significantly reducing Aβ levels and neurodegeneration in 5XFAD transgenic mice by increasing the levels of neprilysin, the endopeptidase responsible for Aβ degradation




Since CB1 receptors are primarily related to the unwanted psychotropic effects of marijuana-derived cannabinoids, the CB2 receptor becomes really attractive as a druggable target. The potential therapeutic use of CB2-agonist in AD is also reinforced by the findings that in the AD human brain, CNR2 (the gene encoding the CB2 receptor) was found to be increased compared to age-matched controls [127]. The anti-inflammatory effects of CB2 agonists have been widely described in different transgenic mouse models of AD and in in vitro AD-like models [128]. Additionally, it was demonstrated that in Aβ-treated mice, cannabinoid treatment prevented microglial activation and avoided induced cognitive impairment


In fact, chronic administration of JWH-133, a selective CB2 receptor agonist, was found effective in reducing tau hyperphosphorylation surrounding Aβ plaques in APP/PS1 mice [132]. Furthermore, mice overexpressing human tau (PK−/−/TauVLW) showed a marked reduction in neurofibrillary tangles with prolonged treatment with Sativex®, an already approved medicine based on mixed Δ9-THC and CBD natural extracts [133]. Due to the multifactorial and sporadic nature of AD, multi-target drugs capable of acting on multiple targets simultaneously (comprising the CB2 receptor) are becoming an attractive therapeutic option in the field of AD


I don't trust the structure of JWH-133, it has squares, seems unstable, very unlike other drugs..


Somehow, I take higher doses of my methylation donors when I'm on weed.

I also took A LOT of dream drops 3 days ago... But it disrupted my sleep for days... Idk if net positive or negative, I sometimes take weed megadoses like 1x-2x a year and idk maybe that induces enough autophagy or VARIANCE at minimum



Omg cannabinoids might decrease ceramides

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  • InquilineKea changed the title to Cannabidiol/cannabinoids/weed/cannabis/marijuana and longevity/autophagy/beta-amyloid clearance?
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