Alex K Chen Posted May 5, 2023 Report Share Posted May 5, 2023 Tomer Ze'ev Favorites · · "..knee cartilage isolated from male and female animals differed significantly in mechanical properties, microstructure, and gene expression long before hormonal changes from menopause. Mechanical tests revealed that bovine cartilage from the males was more than three times stiffer than that from females. When the researchers examined the protein content of this cartilage, they found significant differences in the content of specific protein types in tissue from the male and female animals. Treating individual chondrocytes—the cells that produce cartilage—with an inflammatory chemical changed the activity in different sets of genes between the sexes." MEDICALXPRESS.COM Male, female knee cartilage disparities may explain differences in rates of degeneration Researchers have long known there are sex disparities when it comes to the prevalence and severity of knee osteoarthritis, a disease that causes cartilage degeneration. Now, investigations underway at UT Southwestern Medical Center point to biological differences in the knee cartilage of male and fe... All reactions: 6Kit Arafiles and 5 others 1 comment 1 share Like Comment Share Tomer Ze'ev https://journals.sagepub.com/doi/10.1177/19476035221121792 JOURNALS.SAGEPUB.COM Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage - Paula A. Hernandez, Miranda Moreno, Zahra Barati, Conner Hutcherson, Adwait A. Sathe, Chao Xing, Jamie Wright, Tre Welch, Yasin Dhaher, 2022 Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage - Paula A. Hernandez, Miranda Moreno, Zahra Barati, Conner Hutcherson, Adwait A. Sathe, Chao Xing, Jamie Wright, Tre Welch, Yasin Dhaher, 2022 Like Reply 3d Quote Link to comment Share on other sites More sharing options...
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