Alex K Chen Posted October 26, 2023 Report Share Posted October 26, 2023 (edited) Quote Me, [7/13/2021 14:04 PM] Hey everyone, I've been talking with @yatima1460 and she's seeing a need to have scientific literature published on what DIY MtF ppl have found re:estrogen injection vs using harmful small molecule blockers. Current official state of science is behind what is practically known and it affects availability of substances and makes it more difficult to work with endocrinologists. Seems like a great candidate for some research collective movement! Me, [7/13/2021 14:05 PM] https://transfemscience.org/articles-by-date/ Me, [7/13/2021 14:05 PM] Super cool site Yatima, [7/13/2021 14:12 PM] yeah I need to introduce myself! I'm a DIY HRT trans girl and I want to do something about the current state of HRT Knowledge is so bad and lacking about the current situation that I wouldn't be surprised if even in this group no one knows about how bad it is for trans girls worldwide In short legal HRT is so badly done that the only way to do it healthy is to do it DIY I've read various guidelines for endocrinologists from various countries, only some US stuff is decent the entire EU guidelines are absolutely wrong and damage our health in a legal way if anyone wants to ask questions of any type no problem Deleted Account, [7/13/2021 14:15 PM] What’s the difference between the legal/unhealthy way and the DIY/healthy way? Kaj Jež, [7/13/2021 14:16 PM] @yatima1460 you should qualify that legal approaches vary wildly between jurisdictions (US vs. EU vs. Australia) Yatima, [7/13/2021 14:27 PM] almost everywhere the legal way gives blockers to suppress testosterone when it's known they are bad for health: meningiomas risk, brain fog, liver problems, adrenal glands going crazy and post-finasteride syndrome and other problems the DIY way instead just uses high estradiol blood levels to suppress T and no blockers https://forums.t-nation.com/t/build-muscle-increase-androgen-receptor-density/283880 Quote Surprisingly, the authors of this new paper found that the density of these ARs was the most important determinant in putting on muscle and that actual levels of anabolic hormones don’t play nearly as important a role. Edited January 19 by Alex K Chen Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted January 14 Author Report Share Posted January 14 (edited) https://x.com/prof_horvath/status/1879151906511086058 Breakthrough in Epigenetic Clocks.The "Androgen Clock" offers deep insights into how hormonal regulation shapes DNA methylation. This fully controllable clock only "ticks" when both androgen receptors and androgens are present. • Powered by a single, highly predictive androgen-sensitive DNA site • Accurately tracks long-term androgen exposure in sheep & mice • Detects meat quality issues (e.g., "ram taint" in non-castrated rams) • Clock stops with testes removal & activates in females via synthetic androgens Victoria Sugrue & Tim Hore (2025) "The Androgen Clock Is an Epigenetic Predictor of Long-Term Male Hormone Exposure". PNAS https://pnas.org/doi/10.1073/pnas.2420087121 #Epigenetics #AgingResearch #Biomarkers #Androgens #Longevity #EpigeneticClocks Edited January 14 by Alex K Chen Quote Link to comment Share on other sites More sharing options...
Gordo Posted January 29 Report Share Posted January 29 When you remove yours will you do it yourself? 😂 Quote Link to comment Share on other sites More sharing options...
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