Alex K Chen Posted November 29 Report Share Posted November 29 You can’t measure Klotho accurately, currently. All research labs have in house assays that still cannot distinguish between wild type and KLVS type Klotho. Very frustrating for everyone as this would solve the dosing problem - if only you could measure levels with some level of confidence! I would suggest that you pursue PF4 injections instead. Readily available and tested in people at ridiculously high doses (in a surgical setting) for 20+ yrs. Since it is the main mediator of Klotho - it seems like a no brainer (pun intended!) https://www.nature.com/articles/s41586-023-06436-3 https://www.nia.nih.gov/news/blood-clotting-protein-young-mice-may-rejuvenate-older-mice-brains BioMed Central Blood platelet factor 4: the elixir of brain rejuvenation - Molecular... 5 Quote Link to comment Share on other sites More sharing options...
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