Alex K Chen Posted February 1 Report Share Posted February 1 (edited) I don't have super-favorable variants for longevity according to this survey, but it's unlikely to mean much b/c the very-high impact very-low-frequency alleles aren't accounted for in studies. The genetics don't explain much of anything, nucleus also says I have propensity for obesity and I know for sure as hell that I'm the opposite (and family history also shows opposite) I also have very few alleles for anything high-risk. [this is still better than what I got from just-dna-seq oakvar, whatever it means]. SNP Your genotype Risk / Non-Risk allele Major / Minor allele Minor allele frequency Reported gene rs5762549 T/T T/C T/C 0.34 Not reported rs5999796 G/A A/G G/A 0.33 Not reported rs2823152 T/C T/C C/T 0.38 Not reported rs2827107 A/G A/G G/A 0.37 Not reported rs239648 G/G C/G G/C 0 Not reported rs146101094 G/G T/G G/T 0 Not reported rs4816492 C/C T/C T/C 0.16 Not reported rs2836613 A/A A/G A/G 0.27 Not reported rs140493068 G/G A/G G/A 0.001 Not reported rs1930805 T/T T/C C/T 0.35 Not reported rs6052121 G/T T/G G/T 0.3 Not reported rs76422097 T/T T/C T/C 0 Not reported rs6512705 C/C C/G C/G 0.039 Not reported rs13037253 G/A A/G G/A 0.2 Not reported rs2273500 T/T T/C T/C 0.11 Not reported rs138175288 C/C A/C C/A 0.014 Not reported rs1862260 A/C A/C C/A 0.35 Not reported rs12459965 C/C T/C C/T 0.44 Not reported rs113632670 C/C T/C C/T 0 Not reported rs72976979 C/C T/C C/T 0.006 Not reported rs601338 G/G A/G G/A 0.004 Not reported rs2602691 A/G A/G G/A 0.34 Not reported rs6509691 A/A A/G A/G 0.22 Not reported rs113206366 G/G C/G G/C 0 Not reported rs28926173 G/G A/G G/A 0 Not reported rs182354668 A/A A/C A/C 0 Not reported rs11662237 C/C T/C C/T 0.47 Not reported rs12607270 G/G A/G G/A 0.29 Not reported rs72892761 G/G A/G G/A 0.21 Not reported rs112327574 C/C C/G C/G 0 Not reported rs8067313 G/G T/G G/T 0.4 Not reported rs1011157 C/C T/C C/T 0.24 Not reported rs6503383 T/T T/G T/G 0.13 Not reported rs940088 T/T T/C T/C 0.05 Not reported rs7216344 A/A A/C A/C 0.23 Not reported rs11657291 A/A A/G A/G 0.29 Not reported rs12940850 A/A A/C A/C 0.039 Not reported rs11079570 A/A A/G A/G 0.35 Not reported rs11867618 G/G A/G A/G 0.32 Not reported rs34393853 C/C C/G G/C 0.49 Not reported rs74596054 C/C T/C C/T 0 Not reported rs1641855 C/C C/G C/G 0.088 Not reported rs117658255 C/C T/C C/T 0 Not reported rs12103006 G/G A/G A/G 0.49 Not reported rs117253518 A/A A/G A/G 0 Not reported rs2531995 C/T T/C C/T 0.3 Not reported rs117686120 G/G A/G G/A 0.001 Not reported rs4985461 G/G C/G G/C 0.033 Not reported rs12924886 A/T A/T A/T 0.31 Not reported rs7197858 G/G A/G G/A 0.29 Not reported rs10514518 T/T T/C C/T 0.48 Not reported rs67118461 G/G A/G G/A 0.002 Not reported rs8044280 C/C C/G C/G 0.17 Not reported rs4923920 C/T T/C C/T 0.3 Not reported rs12594483 G/A A/G G/A 0.28 Not reported rs674681 A/A A/G A/G 0.22 Not reported rs13329258 G/G A/G G/A 0.1 Not reported rs35933822 C/C T/C C/T 0.086 Not reported rs952471 C/G C/G C/G 0.37 Not reported rs10851902 A/G A/G G/A 0.3 Not reported rs8042849 T/T T/C T/C 0.16 Not reported rs58484457 T/T T/C T/C 0.31 Not reported rs6224 G/G T/G G/T 0.16 Not reported rs1972926 C/T T/C T/C 0.44 Not reported rs7183703 G/G A/G G/A 0.081 Not reported rs7496118 C/C T/C C/T 0.13 Not reported rs55830546 T/T T/C T/C 0.003 Not reported rs117643465 T/T T/C T/C 0 Not reported rs950197 C/C T/C C/T 0.4 Not reported rs10083495 A/A A/C A/C 0.21 Not reported rs941732 T/C T/C C/T 0.45 Not reported rs751749 A/A A/G A/G 0.084 Not reported rs9588174 A/A A/G A/G 0 Not reported rs77181399 C/C T/C C/T 0.064 Not reported rs9549326 C/C T/C C/T 0.26 Not reported rs7328200 A/G A/G G/A 0.16 Not reported rs10454589 C/C A/C C/A 0.002 Not reported rs1337601 G/G A/G G/A 0.46 Not reported rs112593331 T/T T/G T/G 0.005 Not reported rs139997325 C/C C/G C/G 0 Not reported rs9598295 T/A A/T T/A 0.39 Not reported rs4883780 T/T T/C T/C 0.34 Not reported rs583932 A/A A/T A/T 0.005 Not reported rs4564467 T/T T/C T/C 0.21 Not reported rs9515852 C/C A/C A/C 0.43 Not reported rs12812346 T/C T/C T/C 0.11 Not reported rs597808 G/G A/G G/A 0.004 Not reported rs11066309 G/G A/G G/A 0.003 Not reported rs11057853 C/C T/C T/C 0.43 Not reported Edited February 1 by Alex K Chen Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted February 1 Author Report Share Posted February 1 (edited) Tesi N, van der Lee SJ, Hulsman M, et al. 🔗 Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):750-759. doi: 10.1093/gerona/glaa289. PMID: 33216869. Nucleus will update this report as high-effect variants for longevity are identified. It’s important to remember that science’s current ability to use genetics to predict your longevity is limited. Your polygenic score of -0.564 was derived using association data from Tesi et al., 20202. The amount of phenotypic variance explained by the polygenic score was adjusted based on your ancestry. The estimated broad-based heritability (H²) for longevity is 10-25%2. For a complete explanation of the methodology behind the derivation of these scores, see our technical explainer, Deep dive: For researchers. Edited February 1 by Alex K Chen Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted February 1 Author Report Share Posted February 1 Disease Overall risk Genetic risk Anxiety disorders 50.2% chance Elevated risk Hypertension 39.5% chance Average risk Osteoarthritis 28.0% chance AGE 50-69 Elevated risk Migraine 24.7% chance Elevated risk Age-related macular degeneration 20.9% chance AGE 70-79 Average risk Alcohol dependence 16.3% chance Average risk Insomnia 14.6% chance Elevated risk Alzheimer's disease 10.2% chance AGE 75-84 Average risk Asthma 7.5% chance Average risk Restless legs syndrome 7.0% chance Average risk Prostate cancer 6.8% chance AGE 70+ Average risk Chronic pain 6.4% chance Average risk Coronary artery disease 6.1% chance Average risk Colorectal cancer 5.8% chance Elevated risk Type 2 diabetes 4.8% chance Average risk Depression 4.3% chance Average risk ADHD 4.3% chance Average risk Parkinson's disease 2.0% chance Average risk Bipolar disorder 1.8% chance Average risk OCD 1.5% chance Average risk Schizophrenia 1.1% chance Elevated risk Gastric cancer 1.0% chance Average risk Rheumatoid arthritis 0.3% chance AGE 65+ Decreased risk Celiac disease 0.3% chance Average risk Multiple sclerosis 0.2% chance Average risk Male breast cancer 0.2% chance Average risk 2-methylbutyrylglycinuria Extremely low Extremely low risk 3-M syndrome 1 Extremely low Extremely low risk 3-M syndrome 3 Extremely low Extremely low risk 3-methylcrotonyl-CoA carboxylase 1 deficiency Extremely low Extremely low risk 3-methylcrotonyl-CoA carboxylase 2 deficiency Extremely low Extremely low risk Aarskog-Scott syndrome Extremely low Extremely low risk ABCC8-related congenital hyperinsulinism or permanent neonatal diabetes mellitus Extremely low Extremely low risk Abetalipoproteinemia Extremely low Extremely low risk Aceruloplasminemia Extremely low Extremely low risk Achalasia-addisonianism-alacrimia syndrome Extremely low Extremely low risk Achromatopsia 2 Extremely low Extremely low risk Acrodermatitis enteropathica Extremely low Extremely low risk Adams-Oliver syndrome 4 Extremely low Extremely low risk ADAMTSL4-related ectopic lentis disorders Extremely low Extremely low risk Adenosine deaminase deficiency Extremely low Extremely low risk Adrenocorticotropic hormone deficiency Extremely low Extremely low risk Age-related macular dystrophy 1 Extremely low Extremely low risk Age-related macular dystrophy 13 Extremely low Extremely low risk Age-related macular dystrophy 3 Extremely low Extremely low risk Age-related macular dystrophy 4 Extremely low Extremely low risk Age-related macular dystrophy 9 Extremely low Extremely low risk Aicardi-Goutières syndrome 2 Extremely low Extremely low risk Aicardi-Goutières syndrome 3 Extremely low Extremely low risk Aicardi-Goutières syndrome 4 Extremely low Extremely low risk Aicardi-Goutières syndrome 5 Extremely low Extremely low risk AIFM1-related mitochondrial disorders Extremely low Extremely low risk AIPL1 cone rod dystrophy and related disorders Extremely low Extremely low risk AKAP11-related bipolar disorder Extremely low Extremely low risk Alkaptonuria Extremely low Extremely low risk Alpha mannosidosis, types I and II Extremely low Extremely low risk Alpha-1 antitrypsin deficiency Extremely low Extremely low risk Alpha-methylacetoacetic aciduria Extremely low Extremely low risk Alpha-N-acetylgalactosaminidase deficiency, type 1 Extremely low Extremely low risk Alström syndrome Extremely low Extremely low risk Alzheimer's disease 17 Extremely low Extremely low risk Amyloidosis and intermediate primary hypoalphalipoproteinemia 2 Extremely low Extremely low risk Androgen insensitivity syndrome Extremely low Extremely low risk Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis Extremely low Extremely low risk APC-associated polyposis conditions Extremely low Extremely low risk APOB-related familial hypobetalipoproteinemia Extremely low Extremely low risk APOC2-related hypertriglyceridaemia Extremely low Extremely low risk APOC3-related apolipoprotein C-III deficiency Extremely low Extremely low risk Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted February 1 Author Report Share Posted February 1 Traits BMI Your predicted BMI 28.0 Below average Above average Height Your predicted height 5'9" Below average Above average IQ Your IQ prediction Above average Below average Above average Left-handedness Your chance of being left-handed 10.7% Below average Above average Longevity Your chance of living past 80 47.2% Below average Above average Male-pattern baldness Your chance of going bald 65.2% Below average Above average Muscle strength Your muscle strength prediction Above average Below average Above average Risk-taking Your predicted chance of taking risks Average Below average Above average Seasonal allergies Your chance of having seasonal allergies 25.8% Below average Above average Severe acne Your chance of having severe acne 8.0% Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted February 1 Author Report Share Posted February 1 IQ data Scientific details Nucleus will update this report as high-effect variants for IQ are identified. Your polygenic score of 1.68 was derived using association data from Savage et al., 20186. The amount of phenotypic variance explained by the polygenic score was adjusted based on your ancestry. The models used for this report can currently explain a small portion of the variation in IQ6. The estimated broad-based heritability (H²) for IQ is 50%7. For a complete explanation of the methodology behind the derivation of these scores, see our technical explainer, Deep dive: For researchers. Below is an abbreviated list of the SNPs included in the analysis. You can download the complete table here. SNP Your genotype Risk / Non-Risk allele Major / Minor allele Minor allele frequency Reported gene rs10917152 C/C T/C C/T 0.001 Not reported rs7546297 A/G G/A A/G 0.3 Not reported rs12035012 C/A C/A C/A 0.35 Not reported rs4636447 A/G A/G A/G 0.34 Not reported rs2842188 C/C T/C C/T 0.23 Not reported rs4660749 G/G G/T G/T 0.086 Not reported rs1831539 C/C C/T T/C 0.46 Not reported rs2420551 A/A T/A A/T 0.023 Not reported rs12128707 A/A G/A A/G 0.14 Not reported rs3128341 C/C C/T C/T 0.054 Not reported Quote Link to comment Share on other sites More sharing options...
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