Jump to content

Nucleus Genomic Sequencing


Recommended Posts

I don't have super-favorable variants for longevity according to this survey, but it's unlikely to mean much b/c the very-high impact very-low-frequency alleles aren't accounted for in studies.

The genetics don't explain much of anything, nucleus also says I have propensity for obesity and I know for sure as hell that I'm the opposite (and family history also shows opposite)

I also have very few alleles for anything high-risk.

[this is still better than what I got from just-dna-seq oakvar, whatever it means]. 

 

SNP Your genotype Risk / Non-Risk allele Major / Minor allele Minor allele frequency Reported gene
rs5762549 T/T T/C T/C 0.34 Not reported
rs5999796 G/A A/G G/A 0.33 Not reported
rs2823152 T/C T/C C/T 0.38 Not reported
rs2827107 A/G A/G G/A 0.37 Not reported
rs239648 G/G C/G G/C 0 Not reported
rs146101094 G/G T/G G/T 0 Not reported
rs4816492 C/C T/C T/C 0.16 Not reported
rs2836613 A/A A/G A/G 0.27 Not reported
rs140493068 G/G A/G G/A 0.001 Not reported
rs1930805 T/T T/C C/T 0.35 Not reported
rs6052121 G/T T/G G/T 0.3 Not reported
rs76422097 T/T T/C T/C 0 Not reported
rs6512705 C/C C/G C/G 0.039 Not reported
rs13037253 G/A A/G G/A 0.2 Not reported
rs2273500 T/T T/C T/C 0.11 Not reported
rs138175288 C/C A/C C/A 0.014 Not reported
rs1862260 A/C A/C C/A 0.35 Not reported
rs12459965 C/C T/C C/T 0.44 Not reported
rs113632670 C/C T/C C/T 0 Not reported
rs72976979 C/C T/C C/T 0.006 Not reported
rs601338 G/G A/G G/A 0.004 Not reported
rs2602691 A/G A/G G/A 0.34 Not reported
rs6509691 A/A A/G A/G 0.22 Not reported
rs113206366 G/G C/G G/C 0 Not reported
rs28926173 G/G A/G G/A 0 Not reported
rs182354668 A/A A/C A/C 0 Not reported
rs11662237 C/C T/C C/T 0.47 Not reported
rs12607270 G/G A/G G/A 0.29 Not reported
rs72892761 G/G A/G G/A 0.21 Not reported
rs112327574 C/C C/G C/G 0 Not reported
rs8067313 G/G T/G G/T 0.4 Not reported
rs1011157 C/C T/C C/T 0.24 Not reported
rs6503383 T/T T/G T/G 0.13 Not reported
rs940088 T/T T/C T/C 0.05 Not reported
rs7216344 A/A A/C A/C 0.23 Not reported
rs11657291 A/A A/G A/G 0.29 Not reported
rs12940850 A/A A/C A/C 0.039 Not reported
rs11079570 A/A A/G A/G 0.35 Not reported
rs11867618 G/G A/G A/G 0.32 Not reported
rs34393853 C/C C/G G/C 0.49 Not reported
rs74596054 C/C T/C C/T 0 Not reported
rs1641855 C/C C/G C/G 0.088 Not reported
rs117658255 C/C T/C C/T 0 Not reported
rs12103006 G/G A/G A/G 0.49 Not reported
rs117253518 A/A A/G A/G 0 Not reported
rs2531995 C/T T/C C/T 0.3 Not reported
rs117686120 G/G A/G G/A 0.001 Not reported
rs4985461 G/G C/G G/C 0.033 Not reported
rs12924886 A/T A/T A/T 0.31 Not reported
rs7197858 G/G A/G G/A 0.29 Not reported
rs10514518 T/T T/C C/T 0.48 Not reported
rs67118461 G/G A/G G/A 0.002 Not reported
rs8044280 C/C C/G C/G 0.17 Not reported
rs4923920 C/T T/C C/T 0.3 Not reported
rs12594483 G/A A/G G/A 0.28 Not reported
rs674681 A/A A/G A/G 0.22 Not reported
rs13329258 G/G A/G G/A 0.1 Not reported
rs35933822 C/C T/C C/T 0.086 Not reported
rs952471 C/G C/G C/G 0.37 Not reported
rs10851902 A/G A/G G/A 0.3 Not reported
rs8042849 T/T T/C T/C 0.16 Not reported
rs58484457 T/T T/C T/C 0.31 Not reported
rs6224 G/G T/G G/T 0.16 Not reported
rs1972926 C/T T/C T/C 0.44 Not reported
rs7183703 G/G A/G G/A 0.081 Not reported
rs7496118 C/C T/C C/T 0.13 Not reported
rs55830546 T/T T/C T/C 0.003 Not reported
rs117643465 T/T T/C T/C 0 Not reported
rs950197 C/C T/C C/T 0.4 Not reported
rs10083495 A/A A/C A/C 0.21 Not reported
rs941732 T/C T/C C/T 0.45 Not reported
rs751749 A/A A/G A/G 0.084 Not reported
rs9588174 A/A A/G A/G 0 Not reported
rs77181399 C/C T/C C/T 0.064 Not reported
rs9549326 C/C T/C C/T 0.26 Not reported
rs7328200 A/G A/G G/A 0.16 Not reported
rs10454589 C/C A/C C/A 0.002 Not reported
rs1337601 G/G A/G G/A 0.46 Not reported
rs112593331 T/T T/G T/G 0.005 Not reported
rs139997325 C/C C/G C/G 0 Not reported
rs9598295 T/A A/T T/A 0.39 Not reported
rs4883780 T/T T/C T/C 0.34 Not reported
rs583932 A/A A/T A/T 0.005 Not reported
rs4564467 T/T T/C T/C 0.21 Not reported
rs9515852 C/C A/C A/C 0.43 Not reported
rs12812346 T/C T/C T/C 0.11 Not reported
rs597808 G/G A/G G/A 0.004 Not reported
rs11066309 G/G A/G G/A 0.003 Not reported
rs11057853 C/C T/C T/C 0.43 Not reported
Edited by Alex K Chen
Link to comment
Share on other sites

Tesi N, van der Lee SJ, Hulsman M, et al. 🔗 Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):750-759. doi: 10.1093/gerona/glaa289. PMID: 33216869.

Nucleus will update this report as high-effect variants for longevity are identified.

It’s important to remember that science’s current ability to use genetics to predict your longevity is limited.

Your polygenic score of -0.564 was derived using association data from Tesi et al., 20202.
The amount of phenotypic variance explained by the polygenic score was adjusted based on your ancestry.
The estimated broad-based heritability (H²) for longevity is 10-25%2. For a complete explanation of the methodology behind the derivation of these scores, see our technical explainer, Deep dive: For researchers.
Edited by Alex K Chen
Link to comment
Share on other sites

Disease
 
Overall risk
 
Genetic risk
 
 
 
Anxiety disorders
 
50.2% chance
Elevated risk
 
 
Hypertension
 
39.5% chance
Average risk
 
 
Osteoarthritis
 
28.0% chance

AGE 50-69

Elevated risk
 
 
Migraine
 
24.7% chance
Elevated risk
 
 
Age-related macular degeneration
 
20.9% chance

AGE 70-79

Average risk
 
 
Alcohol dependence
 
16.3% chance
Average risk
 
 
Insomnia
 
14.6% chance
Elevated risk
 
 
Alzheimer's disease
 
10.2% chance

AGE 75-84

Average risk
 
 
Asthma
 
7.5% chance
Average risk
 
 
Restless legs syndrome
 
7.0% chance
Average risk
 
 
Prostate cancer
 
6.8% chance

AGE 70+

Average risk
 
 
Chronic pain
 
6.4% chance
Average risk
 
 
Coronary artery disease
 
6.1% chance
Average risk
 
 
Colorectal cancer
 
5.8% chance
Elevated risk
 
 
Type 2 diabetes
 
4.8% chance
Average risk
 
 
Depression
 
4.3% chance
Average risk
 
 
ADHD
 
4.3% chance
Average risk
 
 
Parkinson's disease
 
2.0% chance
Average risk
 
 
Bipolar disorder
 
1.8% chance
Average risk
 
 
OCD
 
1.5% chance
Average risk
 
 
Schizophrenia
 
1.1% chance
Elevated risk
 
 
Gastric cancer
 
1.0% chance
Average risk
 
 
Rheumatoid arthritis
 
0.3% chance

AGE 65+

Decreased risk
 
 
Celiac disease
 
0.3% chance
Average risk
 
 
Multiple sclerosis
 
0.2% chance
Average risk
 
 
Male breast cancer
 
0.2% chance
Average risk
 
 
2-methylbutyrylglycinuria
Extremely low
Extremely low risk
 
 
3-M syndrome 1
Extremely low
Extremely low risk
 
 
3-M syndrome 3
Extremely low
Extremely low risk
 
 
3-methylcrotonyl-CoA carboxylase 1 deficiency
Extremely low
Extremely low risk
 
 
3-methylcrotonyl-CoA carboxylase 2 deficiency
Extremely low
Extremely low risk
 
 
Aarskog-Scott syndrome
Extremely low
Extremely low risk
 
 
ABCC8-related congenital hyperinsulinism or permanent neonatal diabetes mellitus
Extremely low
Extremely low risk
 
 
Abetalipoproteinemia
Extremely low
Extremely low risk
 
 
Aceruloplasminemia
Extremely low
Extremely low risk
 
 
Achalasia-addisonianism-alacrimia syndrome
Extremely low
Extremely low risk
 
 
Achromatopsia 2
Extremely low
Extremely low risk
 
 
Acrodermatitis enteropathica
Extremely low
Extremely low risk
 
 
Adams-Oliver syndrome 4
Extremely low
Extremely low risk
 
 
ADAMTSL4-related ectopic lentis disorders
Extremely low
Extremely low risk
 
 
Adenosine deaminase deficiency
Extremely low
Extremely low risk
 
 
Adrenocorticotropic hormone deficiency
Extremely low
Extremely low risk
 
 
Age-related macular dystrophy 1
Extremely low
Extremely low risk
 
 
Age-related macular dystrophy 13
Extremely low
Extremely low risk
 
 
Age-related macular dystrophy 3
Extremely low
Extremely low risk
 
 
Age-related macular dystrophy 4
Extremely low
Extremely low risk
 
 
Age-related macular dystrophy 9
Extremely low
Extremely low risk
 
 
Aicardi-Goutières syndrome 2
Extremely low
Extremely low risk
 
 
Aicardi-Goutières syndrome 3
Extremely low
Extremely low risk
 
 
Aicardi-Goutières syndrome 4
Extremely low
Extremely low risk
 
 
Aicardi-Goutières syndrome 5
Extremely low
Extremely low risk
 
 
AIFM1-related mitochondrial disorders
Extremely low
Extremely low risk
 
 
AIPL1 cone rod dystrophy and related disorders
Extremely low
Extremely low risk
 
 
AKAP11-related bipolar disorder
Extremely low
Extremely low risk
 
 
Alkaptonuria
Extremely low
Extremely low risk
 
 
Alpha mannosidosis, types I and II
Extremely low
Extremely low risk
 
 
Alpha-1 antitrypsin deficiency
Extremely low
Extremely low risk
 
 
Alpha-methylacetoacetic aciduria
Extremely low
Extremely low risk
 
 
Alpha-N-acetylgalactosaminidase deficiency, type 1
Extremely low
Extremely low risk
 
 
Alström syndrome
Extremely low
Extremely low risk
 
 
Alzheimer's disease 17
Extremely low
Extremely low risk
 
 
Amyloidosis and intermediate primary hypoalphalipoproteinemia 2
Extremely low
Extremely low risk
 
 
Androgen insensitivity syndrome
Extremely low
Extremely low risk
 
 
Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis
Extremely low
Extremely low risk
 
 
APC-associated polyposis conditions
Extremely low
Extremely low risk
 
 
APOB-related familial hypobetalipoproteinemia
Extremely low
Extremely low risk
 
 
APOC2-related hypertriglyceridaemia
Extremely low
Extremely low risk
 
 
APOC3-related apolipoprotein C-III deficiency
Extremely low
Extremely low risk
 
Link to comment
Share on other sites

IQ data

Scientific details
 
 
 
 
Nucleus will update this report as high-effect variants for IQ are identified.

Your polygenic score of 1.68 was derived using association data from Savage et al., 20186.
The amount of phenotypic variance explained by the polygenic score was adjusted based on your ancestry.
The models used for this report can currently explain a small portion of the variation in IQ6. The estimated broad-based heritability (H²) for IQ is 50%7. For a complete explanation of the methodology behind the derivation of these scores, see our technical explainer, Deep dive: For researchers.
Below is an abbreviated list of the SNPs included in the analysis. You can download the complete table here.

SNP

Your genotype

Risk / Non-Risk allele

Major / Minor allele

Minor allele frequency

Reported gene

rs10917152
C/C
T/C
C/T
0.001
Not reported
rs7546297
A/G
G/A
A/G
0.3
Not reported
rs12035012
C/A
C/A
C/A
0.35
Not reported
rs4636447
A/G
A/G
A/G
0.34
Not reported
rs2842188
C/C
T/C
C/T
0.23
Not reported
rs4660749
G/G
G/T
G/T
0.086
Not reported
rs1831539
C/C
C/T
T/C
0.46
Not reported
rs2420551
A/A
T/A
A/T
0.023
Not reported
rs12128707
A/A
G/A
A/G
0.14
Not reported
rs3128341
C/C
C/T
C/T
0.054
Not reported
Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...