BrianMDelaney Posted January 25, 2013 Report Share Posted January 25, 2013 Al Pater wrote (on the list): Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1. Nogueira LM, Lavigne JA, Chandramouli GV, Lui H, Barrett JC, Hursting SD. Cancer Med. 2012 Oct;1(2):275-88. doi: 10.1002/cam4.23. Epub 2012 Aug 6. PMID:23342276 http://onlinelibrary.wiley.com/doi/10.1002/cam4.23/full http://onlinelibrary.wiley.com/doi/10.1002/cam4.23/pdf Thanks to Al for this great news item! We've known for a while that CR isn't an all-or-nothing phenomenon: a bit of CR yields a bit of benefit, more yields more. But here, we see that the way in which CR isn't all-or-nothing is not that the same genes are turned on to increasing degrees (or more frequently during a 24-hour period), but rather that different, additional genes turn on with increasing CR. Fascinating, and very useful! Some CR benefits might not arise at all with milder CR. Link to comment Share on other sites More sharing options...
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