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CR and Rapamycin

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Al Pater just posted an interesting study: PMID:25807975 "Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects."


What is desperately needed are studies showing the *interaction* of CR and Rapa, including at different dosages and CR levels. I see rapa as the strongest candidate for pharmaceutical life extension, a field that has been mostly marked by utter failure. If one were to combine CR and Rapa, what would be the effects?


Tom B.

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