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Interview on Intermittent Fasting with Valter Longo

Michael R

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Hat tip to FightAging! (and an extra reminder from Al Pater) to a series of additional pieces and interviews with Dr. Longo on intermittent fasting and related matters:



IGF-1 & Intermittent Fasting: Discussion with Valter Longo

Valter Longo: Understanding the Biology of Aging

Fasting Triggers Immune System’s Self-Regeneration

Low-protein diet slows Alzheimer’s in mice

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Not a bad interview.  The focus seems to be on a ~5 day fast (possibly every 60 days or suitable schedule) that went from water-only to low calorie/scientifically devised (they mentioned kale chips - *shudder*) to fix the calorie intake without being as harsh as water only.  And it is a human study.  So it is not a daily (once/day eating) or every-other-day feeding regimen.  Discusses the affects too - mostly I just remember them saying you lose muscle/fat on fast but gain back primarily muscle afterward (after calories are resumed, of course).


I was expecting something more along the current wikipedia definition:



One form of intermittent fasting, alternate day fasting (ADF), involves a 24-hour fast followed by a 24-hour non-fasting period. This is sometimes referred to as every other day fasting or every other day feeding. Alternate-day calorie restriction may prolong life span.[3]

Modified fasting involves limiting caloric intake (e.g., 20% of normal) on fasting days rather than none at all. A study suggests that this regimen may retain most of the benefits of intermittent fasting.[3] The scientific literature for intermittent fasting, in its various forms, was extensively reviewed in 2014.[4] Another form involves eating only one meal per day. [5]

More generally, forms may choose to specify various ratios of fasting to non-fasting periods. The BBC2 Horizon documentary Eat, Fast and Live Longer [6] covered people who committed to fasting two non-consecutive days per week. Known as the 5:2 diet, people consumed 400–500 calories (women) or 500–600 calories (men) during the days of fasting. During feed days, the diet was regular.




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Guest Rodney

This looks like it may be the most stunning new information on health I have seen in ten years.  Years ago I was briefly a member of the Yahoo Fasting discussion group.  But it was obvious that no one at the group - which seemed to include a few pretty high-powered scientific researchers - was aware of any serious research on the topic.


Based on the information in the following link it seems pretty clear that the fasting would have to be done on a weekly schedule because the lifespan of white cells is very short:




Might it be that having an immune system in old age that is capable of fighting off pathogens might add ten years to lifespan?  If pneumonia, cancer and infectious diseases could be substantially delayed, the effects could be remarkable, and give Mr. de Grey a little more time to find us all the cure for aging.



(Yes, Michael, I will get around to registering.  Thank you for the suggestion.)

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  • 4 weeks later...

Science Daily reports a new publication by Longo  http://www.sciencedaily.com/releases/2015/06/150618134408.htm

Diet that mimics fasting appears to slow aging Benefits demonstrated in mice and yeast; piloted in humans


" cycles of a four-day low-calorie diet that mimics fasting (FMD) cut visceral belly fat and elevated the number of progenitor and stem cells in several organs of old mice -- including the brain, where it boosted neural regeneration and improved learning and memory."


"Bimonthly cycles that lasted four days of an FMD which started at middle age extended life span, reduced the incidence of cancer, boosted the immune system, reduced inflammatory diseases, slowed bone mineral density loss and improved the cognitive abilities of older mice tracked in the study. The total monthly calorie intake was the same for the FMD and control diet groups, indicating that the effects were not the result of an overall dietary restriction."


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