InquilineKea Posted October 8 Report Share Posted October 8 (edited) G2. I mean more complex, sialyated glycogens are good Glycanage - does rapamycin reduce it? 17 alpha estradiol? Or N-acetyl-D-mannosamine (ManNAc, sialic acid precursor)? Edited November 16 by InquilineKea Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted November 17 Author Report Share Posted November 17 (edited) Edited November 17 by InquilineKea Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted November 20 Author Report Share Posted November 20 (edited) https://link.springer.com/article/10.1007/s11135-022-01543-1 https://www.science.org/doi/10.1126/sageke.2004.16.pe16 It's the complexity loss... Quote IgG-Fc Glycosylation in Humans and in Autoimmunity When analyzing normal IgG repertoire in normal human serum it is found that the overall total glycosylation pattern is, although heterogeneous, generally quite constant, with high fucosylation (96%), low bisection (8%), intermediate galactosylation (40%), and low sialylation (4%) (13). Age and gender are two factors that were found to be correlated with the overall IgG glycosylation patterns. The main variations consist of a decrease in average galactosylation and sialylation and slight increase in bisection associated with higher age (13). The degree of fucosylation is almost 100% shortly after birth (when maternal antibodies have dissipated), after which levels of IgG fucosylation gradually reach ~96% around 20 years of age (14). Infection status, BMI, and epigenetic influences also seem to alter total IgG glycosylation (15–17). == From a chart I saw, it correlates most highly with FEV (lung capacity). it also correlates moderately highly with the proteomic/metabolomic indices of aging, and 0 with Hannum/Horvath Quote Lipsitz and Goldberger (37) have suggested that normal human aging is associated with a loss of complexity in a variety of fractal-like anatomic structures and physiological processes. This loss of complexity is manifest as degradation in fractal scaling (for example, breakdown in bone trabecular architecture or loss of 1/f scaling of cardiac interval time series); narrowing of a frequency response (for example, loss of the ability to hear high-frequency sounds); loss of long-range correlations in time series data (for example, cardiac interval, BP, or stride interval time series); increased randomness or stochastic activity (for example, cardiac intervals or postural sway trajectories); or greater periodicity [for example, slow, regular, electroencephalographic waves (electrical activity produced by the brain)]. Using a variety of measures that employ fractal analysis, aging has been shown to be associated with a loss of complexity in BP (29), respiratory cycle (10), stride interval (26), and postural sway dynamics (38). You can have complexity loss while still being free of most of the "top causes of death" biomarkers... I mean, a lot of this is related to gero.ai.. (though gero.ai doesn't quantify it *all* well, it's best with a polar HRV)../. https://www.nature.com/articles/s43587-022-00252-6 Edited November 20 by InquilineKea Quote Link to comment Share on other sites More sharing options...
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