Gangliosides (like GM1) - how to measure? Their sialic acid may be anti-inflammatory (and may be related to Glycanage). Is higher Glycanage predictive of reduced ganglioside synthesis?

[Alex K Chen]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ST6GAL1

 

https://www.frontiersin.org/articles/10.3389/fnins.2020.572965/full

https://glycanage.com/glycanhub/podcast/season-1/glycans-and-neurodegenerative-diseases-a-new-perspective-on-alzheimers-with-prof-ronald-schnaar

Quote

During brain development, the ganglioside pattern changes from the prevalence of the simple gangliosides GM3 and GD3 to more complex ones such as GD1a and GT1b [66] (for structures, see Figures Figures77 and and11).11). Ganglioside content and composition of the brain change also during aging: for example, the amount of lipid-bound sialic acid decreased from 1070 μg/g wet weight in a 25-year-old healthy proband to 380 μg/g wet weight in a 85-year-old individual. Despite this, the concentrations of GQ1b, GT1b, and GD1b increase with age at the expense of GM1 and GD1a

GM1 = 4 chain, GM3 = 1chain

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02374-x

Edited November 17, 2023 by InquilineKea

[Alex K Chen]

Edited November 17, 2023 by InquilineKea