Does pregnancy age people faster *and* rejuvenate the woman through parabiosis?

[Alex K Chen]

Pregnancy is A LOT of stress that accelerates epigenetic clocks, but SOME of that is reversible (see jesse pogalnick). Also, women go under the opposite of CR while pregnant (and pre-pregnant) and this accelerates aging.

But otoh, there's parabiosis between mom and child while the child is still in the womb.

From everything I know, becoming supercentenarian is not super-correlated with having (or not having) children (both childfree and child-bearing women have the chance)

Maria Entraigues Abramson might be a super-ager and she never got pregnant.

Idk how pregnancy affects age of menopause. Also, pregnancy shrinks brain size.

 

Edited February 24 by InquilineKea

[Alex K Chen]

There is ample evidence that having a small number of children actually
extends their average lifespan. decreases overall mortality risk. For
example, see: https://pubmed.ncbi.nlm.nih.gov/23176782/
Perhaps the extraordinary (if common!) state of being pregnant causes some
of the age-associated biomarkers to detour, and express differently than
they do during non-pregnancy, i.e., for the general (overwhelmingly not
pregnant) population that are used to train the clock.

[IgorF]

Coleen Murphy in her recent book "How We Age: The Science of Longevity" mentions it many times - the less children - the better woman's chances for longevity. It should be easy to derive this from the fact that igf1/insulin-related areas heavy involvement in fetal and post-natal growth (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779855/) will not left unnoticable for her body also.