Alex K Chen Posted August 5, 2020 Report Share Posted August 5, 2020 They evidently used them here - https://www.medrxiv.org/content/10.1101/2020.07.07.20148098v1?fbclid=IwAR1fovyX_f_d97G_bn6QjojBBBRaNFLlFhaOBKKhke8HS5DaA4r4Oj6Hq1o Quote Link to comment Share on other sites More sharing options...
Sibiriak Posted August 5, 2020 Report Share Posted August 5, 2020 (edited) Quote The dietary recommendations employed as part of the treatment protocol for this study were based largely on biochemistry and generalized measures of health, because few dietary associations with the DNAmAge clock have yet been established. A modest, but significant, reduction in DNAmAge in individuals consuming a non-specific lean meat, fish and plant-based diet (as measured by blood carotenoids) has been observed (Quach et al., 2017). It is possible that changes of a greater magnitude require a more targeted approach. The dietary intervention used here was also plant-centered, but including a high intake of nutrients that are substrates or cofactors in methylation biosynthetic pathways (e.g. containing folate, betaine), ten-eleven translocation demethylase cofactors and modulators (e.g. alpha ketoglutarate, vitamin C and vitamin A) (Hore, 2017) and polyphenolic modulators of DNA methyl transferases (DNMT) (e.g. curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin). It also included limited nutrient-dense animal proteins (e.g. liver, egg). The diet restricted carbohydrates and included mild intermittent fasting, both designed to lower glycemic cycling. The diet was supplemented daily with a fruit and vegetable powder, also rich in polyphenolic modulators of DNMT activity , and a probiotic providing 40 million CFU of Lactobacillus plantarum 299v. L. plantarum has been shown to be a folate producer in the presence of para aminobenzoic acid (PABA) (Sybesma et al., 2003); it also has been demonstrated to alter gene expression (Hariri et al., 2015). Vegetable and fruit powders are more dense in micronutrients/phytochemicals than whole vegetables/fruits because their water content (and often fiber) has been removed ( by freeze-drying, for example). Although they may possibly be useful as special supplements at times, they are not cost-effective and certainly cannot replace whole foods which are the foundation of a WFPB diet. Edited August 5, 2020 by Sibiriak Quote Link to comment Share on other sites More sharing options...
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