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PGE2 and mitigating cognitive decline


corybroo
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Decline seems to be reversed but I doubt that lost memories would be recovered.

Cognitive decline due to aging can be reversed in mice – here's what the new study means for humans

Now a new study published in Nature reveals that microglia—a type of white blood cells found in the brain—are extremely vulnerable to changes in the levels of a major inflammatory molecule called prostaglandin E2(PGE2).

the researchers found that these effects occurred only because of PGE2's interaction with one specific receptor on the microglia. By disrupting it they were able normalize cellular energy production and reduce brain inflammation. exposure to this molecule badly affected the ability of microglia and related cells to generate energy and carry out normal cellular processes.

Fortunately, the researchers found that these effects occurred only because of PGE2's interaction with one specific receptor on the microglia. By disrupting it they were able normalize cellular energy production and reduce brain inflammation. 

exposing these white blood cells to PGE2 suppressed the ability of their mitochondria 

[They] genetically modified animals to [remove] the EP2 receptor … the old genetically modified mice learned and remembered just as well as their young counterparts. 

There is also evidence that [blueberries, strawberries, spinach, and other fruit & vegetables] block PGE2 at the cellular level,

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