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Longevity-Associated Triglycerides

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Most ether PC species showed a negative association, while all other longevity-associated lipids displayed a positive association with age, except for SM (d18:1/18:2) and (d18:1/23:0), which were not significantly affected by age. The most significant effect of age was observed for ether PC (O-34:3) and (O-36:3) showing negative and TG (52:1), (54:7), and (57:2) showing positive associations with age


Nevertheless, the molecular characterization of individual triglyceride molecules involved in atherogenesis and increasing age in women remains elusive (Schwartz & Reaven, 2012). Four of the triglyceride species of the longevity profile, TG (54:7), TG (54:6), TG (56:7), and TG (56:6), are long-chained and highly polyunsaturated, and thus, they are considered highly peroxidizable. Typically, long-chain triglycerides undergo beta-oxidation in mitochondria or peroxisomes whose enzymatic capacity decreases with age. Deleterious PE (38:6) and most TG species increased at a slower rate in female offspring after 55 years compared with controls. Therefore, lower levels of unsaturated TG species in female offspring may reflect an efficient beta-oxidation function compared to controls

Wtf are 58:7 and 58:11 made of? These seem highly polyunsaturated and peroxidable...

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