Michael R Report post Posted August 16, 2016 All: Shoot ... I really thought that someone had already posted this! My bad .... Some amazing science already, particularly Cohen's work on mitochondrially-derived peptides. Everything very high-level (meaning not granular) this year. Sign up if you still can and tune in! Share this post Link to post Share on other sites
Dean Pomerleau Report post Posted August 16, 2016 I literally started a post about RB2016 yesterday, but then abandoned it after looking over the program, and not seeing any talks or speakers that seemed very interesting. From the overview of Cohen's research, it does look interesting. I'm disappointed I missed it. --Dean Share this post Link to post Share on other sites
KHashmi317 Report post Posted August 25, 2016 (edited) All: Shoot ... I really thought that someone had already posted this! My bad .... Some amazing science already, particularly Cohen's work on mitochondrially-derived peptides. Everything very high-level (meaning not granular) this year. Sign up if you still can and tune in! I'm subscribed to the SENS YouTube channel, and was updated immediately. The full (unedited) multi-hour video was posted immediately after the LiveStream (both days). Hopefully, they'll chunk it to separate presentations as they have in prev. years. Personal fave: Judith Campisi on cancer. Edited August 25, 2016 by KHashmi317 Share this post Link to post Share on other sites
KHashmi317 Report post Posted September 1, 2016 (edited) Hopefully, they'll chunk it to separate presentations as they have in prev. years. Which indeed seems to be the case. Here's AdG himself with a quick opener, surprisingly featuring a lot of pure CR content ... A good slide is: Edited September 1, 2016 by KHashmi317 Share this post Link to post Share on other sites
KHashmi317 Report post Posted September 1, 2016 (edited) Now going thru Pinchas Cohen KEYNOTE presentation here ... Cohen's key focus is on relatively-newly discovered humanin peptide (link to Cohen's USC Lab): Recent studies identified a novel mitochondrial-derived peptide (MDP) named humanin. Humanin (HN) is a 24 amino-acid peptide, encoded from the 16S ribosomal RNA region of the mitochondrial DNA, originally described as a neurosurvival factor capable of antagonizing Alzheimer's disease-related cell death insults. We have also shown that HN has potent actions on many processes related to aging, such as development in zebrafish, insulin sensitization, and beta-cell function. I Googled "humanin peptide calorie restriction" and came up with almost zilch. (I was looking for the usual up/down regulation link between CR and molecule; e.g., CR and IGF, etc.). Wiki notes: "The Cohen lab (Pinchas Cohen) independently discovered humanin when screening for proteins that interact with IGFBP3". Although Cohen does note humanin's "similarity to CR/fasting", methinks no researcher has yet formally investigated humanin/CR link(s). Is this correct? EDIT: Any CR/humanin correlation makes me wonder about other correlations ... like humanin and that vulgar "p-word" ... p-p-p-p-p-protein. Specifically, protein intake. Sample slide from Cohen 2016: Edited September 1, 2016 by KHashmi317 Share this post Link to post Share on other sites
