Saul Posted October 22, 2019 Report Share Posted October 22, 2019 Today from Science News: Another article involving the important research being conducted here at the University of Rochester: Microglia had been thought to be active all the time; not so; they are most active during sleep, especially when we are not stressed (low circulating noreprinephine) https://www.urmc.rochester.edu/news/story/5584/the-night-gardeners----immune-cells-rewire-repair-brain-while-we-sleep.aspx Quote Link to comment Share on other sites More sharing options...
mccoy Posted October 22, 2019 Report Share Posted October 22, 2019 After having read the posted article, I wonder about the implications with CE. Cold stimulates the secretion of norepinephrine, which inhibits microglial activity...But the microglials are most active during (deep) sleep, when we usually do not practice CE (otherwise we probably wouldn't be able to sleep at all). Quote Link to comment Share on other sites More sharing options...
Saul Posted October 22, 2019 Author Report Share Posted October 22, 2019 Probably irrelevant to CE. Possibly more important to "General Health and Longevity" than e.g CE. ( I'm a CE agnostic, but a strong believer is the importance of sleep.) -- Saul Quote Link to comment Share on other sites More sharing options...
mccoy Posted October 22, 2019 Report Share Posted October 22, 2019 1 9 minutes ago, Saul said: Probably irrelevant to CE. Possibly more important to "General Health and Longevity" than e.g CE. ( I'm a CE agnostic, but a strong believer is the importance of sleep.) -- Saul In theory, CE might influence microglial circulation during sleep, since CE stimulates norepinephrine and microglia are inhibited by such substance. But I doubt that norepinephrine during sound sleep is secreted in significant amounts since norepinephrine would tend to inhibit sleep as well... Unless specific conditions exist. Quote Link to comment Share on other sites More sharing options...
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