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mccoy

Stemtalk episode 98

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In this episode, Steven Austad, talks in the first 40 minutes of his peculiar career. Afterward the discussion deals with longevity and lifespan in animals and humans. At a certain point, CR and the CR society is mentioned, plus all the various experiments on CR in rodents. He cites studies where various genetic strains of lab rats have been CRed and the results distributed homogeneously in 3 tertiles: one third lived longer, one third the same, one third less on a CR regime. His conclusions is that CR has different effects according to the individual genetic makeup of rodents (of course the issue is very interesting if extrapolable to humans, implying that in some people CR may be deleterious instead of beneficial).

Has this issue been discussed elsewhere in this forum and are the results exactly as Dr Austed describes them?

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1 hour ago, mccoy said:

Has this issue been discussed elsewhere in this forum and are the results exactly as Dr Austed describes them?

Yes it has been discussed, e. g. here and here, and yes some strains of mice live shorter lives on CR. In the second link I too use the variation in CR benefits (or harm) between mouse strains to argue CR is not likely to be a panacea for human longevity.. 

--Dean 

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Thanks Dean, and I'm quoting here a sentence of yours in the first link you provided:

Quote

Interestingly, in light of the discussion on the Genetics of Obesity thread about whether a tendency towards obesity is a good or bad thing, a follow up analysis by the same authors [2] found that among these mice strains, those that were able to preserve the most fat (due to genetic variations) when subjected to food restriction benefited the most. Those mice that couldn't maintain fat on food restriction, died early(ier). They conclude "[genetic] factors associated with maintaining adiposity are important for survival and life extension under DR."

That sounds logically sensible, as a first order principle. So maybe we're dealing with the issue, discussed in other threads, of the BMI optimum in humans (as a proxy for adiposity optimum).

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