Jump to content

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Recommended Posts

23 hours ago, Saul said:

The subjects were overweight; it's more a study of the positive effects of reducing obesity.

  --  Saul

If "the subjects" means all, then that's not true: 107 subjects had a BMI of 22 - 24.9 (not overweight), whereas 113 had a BMI of 25 - 27.9 (overweight).

So about half were overweight in both the CR and control groups.

Link to comment
Share on other sites

  • 9 months later...

The idea that only the DunedinPACE test detected the benefit is wrong or at least misleading. The effect size was so small that detecting it via point-estimates (the kind of other tests used) was within the noise. Ie, such a small benefit is not detectable by point-estimate tests. One would need a bigger effect size (eg by doing the intervention longer or using higher % CR or using a better intervention). See this thread on Twitter (which Mike was also a participant in): 


Link to comment
Share on other sites

Mike, I posted here just for completeness. I don't check these forums often but above in this thread you wrote, "Arguably the most important data in that study is that the DunedinPACE test is the only epigenetic test to identify a biological age reduction for people on CR, relative to other epigenetic tests" which gives the impression that only DunedinPACE was "good" (if one believes in CR, as many here do), so I thought it was important for those here to have a pointer to that Twitter thread in which these issues were well hashed out. Twitter thread forks make it hard to find the exact right Tweet to link to so I did best I could linking to one where the key points were right below but one could scroll up for full context. The key points in the next few Tweets from the one I linked were Olafur agreeing with the Tweet I linked that PCGrimAge wouldn't be able to detect a real CR effect in this trial design, me saying 'So doesn't that invalidate the "I think the fact that PC GrimAge was not improved by 24 month of CR is strongly indicative of that clock not being good" sentiment?' in response to an upthread Tweet and then him agreeing. That was the main point.

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Create New...