mccoy Posted October 8, 2023 Report Share Posted October 8, 2023 I found this simple, concise review. I wanted to find out about the causes, but apparently, it all comes down to coronary occlusion and ensuing plaque detachment and myocardial occlusion. https://www.ncbi.nlm.nih.gov/books/NBK537076/#:~:text=Most myocardial infarctions are due,myocardial cell death and necrosis. Also, it is nice to have a list of the main hazard factors, coming from the cardiologists, the Interheart study. Not that I do not believe the prevention specialists, but checking doesn't hurt. Smoking, elevated ApoB and ApoA and hypertension are the 3 risk factors that top the list. We knew that, but it is good to have some confirmation from another source besides Peter Attia. Alcohol consumption is officially regarded as weakly protective. We already discussed that, the weak protection comes with an association (weak?) with cancer. Quote As stated above, myocardial infarction is closely associated with coronary artery disease. INTERHEART is an international multi-center case-control study which delineated the following modifiable risk factors for coronary artery disease:[5][6] Smoking Abnormal lipid profile/blood apolipoprotein (raised ApoB/ApoA1) Hypertension Diabetes mellitus Abdominal obesity (waist/hip ratio) (greater than 0.90 for males and greater than 0.85 for females) Psychosocial factors such as depression, loss of the locus of control, global stress, financial stress, and life events including marital separation, job loss, and family conflicts Lack of daily consumption of fruits or vegetables Lack of physical activity Alcohol consumption (weaker association, protective) Quote Link to comment Share on other sites More sharing options...
mccoy Posted October 8, 2023 Author Report Share Posted October 8, 2023 Wikipedia also has a good review on MI. It cites other causes as well, such as the Takotsubo syndrome. Quote MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress (commonly known as Takotsubo syndrome or broken heart syndrome) and extreme cold, among others. https://en.wikipedia.org/wiki/Myocardial_infarction Quote Link to comment Share on other sites More sharing options...
mccoy Posted October 8, 2023 Author Report Share Posted October 8, 2023 https://en.wikipedia.org/wiki/Takotsubo_cardiomyopathy Takotsubo syndrome seems to be responsible for about 2% of events worldwide. Pure coronary occlusion appears to be the overwhelming risk. Quote Link to comment Share on other sites More sharing options...
drewab Posted October 8, 2023 Report Share Posted October 8, 2023 Thanks for sharing the review mccoy! I recently saw these two images and they come to mind in the context of your post. They are taken from autopsies in the brain of patients with (or without) atherosclerosis. It is obvious about the kind of blood vessels we want. Here are some squeaky clean blood vessels free from disease. Here are some heavily diseased vessels that would undoubtably contribute to increased mortality rates and lower quality of life. Quote Link to comment Share on other sites More sharing options...
mccoy Posted October 8, 2023 Author Report Share Posted October 8, 2023 😬... Just looking at the occlusions almost makes me feel the brain stroke.... Quote Link to comment Share on other sites More sharing options...
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