Todd Allen Posted July 11, 2016 Report Share Posted July 11, 2016 The words "new" and "CR" seem like they don't really go together. I'm in a weight loss phase. If I achieve a low stable weight and maintain it with a low calorie nutritious diet then I think the term CR will be more fitting. Anyway, I did 3 weeks of 1000 calories/day by going cold turkey on all high glycemic crappy carbs and greatly reducing much of the better carbs such as fruit too. I then switched to roughly 1900-2000 calories/day to slow weight loss to roughly 1 lb/week. I've been increasing consumption of better carbs such as fruit, sweet potatoes and quinoa. Currently, I'm eating roughly 17% protein, 37% fat and 46% carbs and am meeting my basic nutritional needs as checked by CRON-O-METER, except for modest deficiencies of B12 and D for which I take supplements. I'm 5'10" and my weight had dropped from 174 to 161 lbs at the time of my most recent blood tests and I'm continuing to lose a pound/week which I plan to sustain until I've lost my pinchable fat which ought to take me to 130 lbs or maybe lower. I was drawn to CR as potentially therapeutic for my inherited neuro-muscular disorder SBMA, aka Kennedy's disease. I also have poor biomarkers for CVD and was hoping for improvement. My mother suffered terribly from numerous strokes in her 50s and 60s and in April I lost a friend with SBMA only a little older than myself, 51, to a stroke which moved me to action. My resting pulse and blood pressure have been improving quickly. BP is down about 25 points and lately is in the range of 120-130/80-90. I've also been exercising, improving rapidly from being barely able to walk to walking rough 3 miles/week, bicycling 30 miles/week and doing ~10 hours/week of other exercise mostly indoors. For a couple weeks I was exercising in all forms for a much greater number of hours but I stopped making gains. Incorporating longer periods of rest between exercising I'm making good gains again. I got blood test results on Friday and spent some time this weekend trying to understand them. Here are my results and current thoughts. CPK 1432, 1144 6 mo ago, ref range 9-185 U/LThis is an indicator of muscle damage, I was hoping my change in diet and supplements would minimize the increase with resumed exercise. I was at 1760 a few years ago when I stopped exercising and far higher in my early 30s when I exercised vigorously and was doing 100 mile bicycle rides. My loss of muscle since then may be the reason it hasn't risen as high this time, or maybe the combination of things I'm doing now is helping a little.aldolase 16.2, 18.2 2 yrs ago, ref range 2-8 U/LThis is another indicator of muscle damage. It's an enzyme found in muscle involved with glucose metabolism. The dropping level might be a sign that my regimen for addressing SBMA is helping or it might merely be an indication of my diet shifting me towards metabolizing more fatty acids and less glucose. I need to find guidance to better understand this.Testosterone binding globulin, 81, ref range 10-80 mmol/LTestosterone accelerates SBMA, my mother had high testosterone and developed significant symptoms of SBMA in her late 40s. I had a previous test a few years ago which also showed me above the reference range. I've been told testosterone fluctuates and individual tests aren't that meaningful. I was hoping my diet would have lowered it more and perhaps it eventually will. I'm going to push this strongly now with my doctors to further evaluate and hopefully come up with a way to get my level to the bottom of the reference range or lower. Dutasteride, a testosterone antagonist, is a drug that has been trialed for SBMA that I believe was shown to be modestly beneficial. I'll look into it more closely and try to decide if the benefits might outweigh the risks in my case.human growth hormone, <0.1, ref range <10.8 ng/mL (they noted checking this twice to rule out making an error)HGH may slow SBMA. In a study of a mouse model of SBMA growth hormone (I think IGF1 specifically) was shown to promote muscle regeneration and preserve nerve function. I wasn't expecting this result though it might explain a lot. I've long felt I've had little capacity to recover from injury. When my wisdom teeth were extracted a lingual nerve was bruised resulting in a burning sensation in my tongue. The surgeon said this was common and would resolve in a couple weeks, but 15 years later it has only subsided from a fierce burning to a mild burning. And strenous high intensity activity such as body building style weight lifting or any exertion that results in deep muscle strain can take 2 or 3 weeks to recover instead of the 2 or 3 days that it should. I know human growth hormone is used therapeutically for some conditions and I need to find out if it is appropriate for me though too much is associated with cancer and other aging related issues.MCV, 96.6, 93.2 6 mo ago, ref range 81-99 fLThis is a measure of the size of red blood cells. High results can be an indicator of macrocyctic anemia a condition that can develop in response to a B12 deficiency. A few years ago I was found to have a severe B12 deficiency which was immediately addressed by a series of injections. And followed that with an oral B12 supplement for maintenance. My neurologist was deeply alarmed as B12 deficiency causes neurological damage that untreated can become so severe it results in death. B12 is found in animal based food products such as meat, fish, eggs, dairy, etc. I had been eating mostly vegetarian for decades for ecological reasons and thinking without doing any research that I was eating relatively healthy and was oblivious to the risk of B12 deficiency without supplementation. I had read that vitamin supplementation in general is unneeded for those with good diets and assumed I was doing ok. And for years I was developing neuropathies consistent with B12 deficiency that my doctors and myself assumed was somehow related to SBMA and failed to properly investigate. My doctors knew I was eating mostly vegetarian and still failed to find this for a very long time. The supplement I take is 500 mcg which claims is 8000% of the rda. It seemed ridiculously high so I faded back to taking it roughly once/week. With the tests showing my MCV value is again rising I'm going back to once/daily.MCHC, 33.3, 34.9 6 mo ago, ref range 32-35 g/dLWhen high it is another potential indicator of B12 deficiency, so I'm glad to see it falling and it might indicate increasing B12 supplementation is not needed. Supposedly there is little to no risk with supplementing B12 at too high a level so it seems most prudent to go back to the higher level for now.WBC, 7.4, 6.8 6 mo ago, ref range 3.5-11.0 10*3/uLRBC, 5.22, 5.17 6 mo ago, ref range 4.47-5.91 10*3/uLhemoglobin, 16.8, 16.8 6 mo ago, ref range 13.5-17.5 g/dLhematocrit, 50.4, 48.2 6 mo ago, 41-53%RBC dist width, 13.1, 13.2 6 mo ago, ref range <14.3%platelet count, 265, 254 6 mo ago, 150-450 10*3/uLmean platelet volume, 12.0, 11.7 6 mo ago, ref range 9.0-12.6 fLAll are ok?albumin, 5.2, 4.9 6 mo ago, ref range 3.5-5.0 g/dLIncreased blood albumin may be due to dehydration or a high protein diet. I've boosted protein intake and increased it as a percentage of my diet by reducing carbohydrates in an effort to retain lean muscle mass while dieting to lose fat. I only drink water now and I'm drinking a lot more, still I think the rising albumin is an indicator more of dehydration than protein as I've long had an issue with periods of greatly elevated urine flow - such as experienced by diabetics, though I've never been found to show insulin insenitivity. I believe the urination issue (and many other issues I've had) are related to elevated norepinephrine. In the past I tried to get my doctors to look at this more closely and was referred to a psychologist which resulted in prescriptions for anti-anxiety medications I never filled or took. Hopefully now that I have multiple blood tests showing other hormone imbalances such as the elevated testosterone and lack of growth hormone I can get some traction with an endocrinologist and get this properly investigated.C-reactive protein, <3, <3 3 yrs ago, ref range <5 mg/LESR westergren, 4, 3 1 yr ago, ref range 0-25 mm/HrThese are markers for inflammation. I think these numbers are ok. I believe my low carbohydrate diet ought to be anti-inflammatory and my increased exercise might be increasing it short term, but long term ought to be anti-inflammatory as my fitness improves. I've started eating some flax and chia both rich in omega 3 fatty acids which should be anti-inflammatory at least with respect to cardiovascular health. I've also begun taking a DHA/EPA supplement Ovega-3 500 mg/day.glucose ser/plasma 92, ref range 60-109 mg/dLHigher than I expected given my low carb diet. Maybe this is elevated by high norepinephrine?chloride 98, ref range 95-108 mmol/Lsodium 141, ref range 134-149 mmol/Lpotassium ser/plasma 4.5, ref range 3.5-5.0 mmol/Lanion gap 18, ref range 6-15 mmol/LI'm glad my potassium level is not too high as I take potassium losartan for blood pressure and eat a lot of potassium rich foods. I think the high anion gap is a calculated value which is due to my chloride being low normal and my sodium being higher. And I think that may be a normal side effect of the diet I'm on.carbon dioxide 25, ref range 23-30 mmol/LI think this low normal value is good. Being too low can be a sign of dehydration or liver or kidney damage.BUN 15, ref range 7-20 mg/dLcreatinine 0.5, ref range 0.5-1.4 mg/dLglomerular filtration rate estimate, >120, ref range >59 mL/min/BSACreatinine is probably low due to having low muscle mass and maybe also due to high urine volume. The high calculated GFR is probably meaningless if the low creatinine level is just due to having little muscle.calcium, 10.2, ref range 8.4-10.2 mg/dLHigh normal is hopefully ok. Too high can indicate excess parathyroid hormone leaching calcium from bones. This would be bad in combination with long term caloric restriction which can accelerate loss of bone density, especially with aging. Could my other hormone abnormalities be related to elevated PTH?bilrubin total, 0.4, ref range 0.1-1.0 mg/dLok?total protein, 8.0, ref range 6.0-8.3 g/dLHigh normal hopefully just another indication of mild dehydration?alk phos serum 32, ref range 30-120 U/LLow normal hopefully indicates a healthy liver? My vitamin D level was low this winter and I began taking 1000 IU/day and I've been getting more sun with the warmer weather. Coeliac disease is also listed as a cause of low levels. I don't think I have it, though I do get a coeliac type of response to eating most legumes which I've been increasingly avoiding for the past few years.AST (SGOT), 66, ref range 8-37 U/LALT (SGPT), 53, ref range 8-35 U/LProbably due to high CK and hopefully not indicative of liver dysfunction. I've been taking vitamin B3 as nicotinamide riboside 250 mg/day and recently added B3 as nicotinic acid 500 mg/day which at higher levels can lead to liver issues.cholesterol 228, ref range 120-199 mg/dLHDL cholesterol 58, ref range 40-80 mg/dLLDL cholesterol 123, ref range 60-129 mg/dLtriglycerides 235, ref range 30-149 mg/dL They've all been poor for a long time. I had a doctor want to get me started on statins when I was 30 which I refused because the list of side effects was the list of issues I was already experiencing to some degree. I was hoping my low carb fat burning diet would have lead to a bigger improvement. My guess this is due to my hormone imbalances in particular having elevated norepinenphrine. Nicotinic acid at higher doses is good for reducing cholesterol with increasing risk for liver trouble. Link to comment Share on other sites More sharing options...
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