Todd Allen Posted August 28, 2018 Report Share Posted August 28, 2018 (edited) oops, posted this in the wrong forum - meant to post to general health & longevity. Is it possible to move or delete/repost? --- https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqy117/5052139?guestAccessKey=c18b1acf-2778-42b9-8d72-878c0e86cdbf DISCUSSION In this prospective study in older US adults, we evaluated, for the first time to our knowledge, the associations of serial measures of circulating fatty acid biomarkers of dairy fat with total mortality, cause-specific mortality, and incident CVD. In multivariable analyses, none of these fatty acids were associated with total mortality. Higher plasma phospholipid heptadecanoic acid was associated with lower CVD mortality, especially stroke mortality, with a 42% lower risk of the latter when comparing participants in extreme quintiles. In contrast, pentadecanoic acid, but not heptadecanoic or trans-palmitoleic acids, was associated with a trend toward a higher risk of total CVD and CHD across quintiles, although this association should be interpreted cautiously because it was not significant within any of the individual quintiles or in analysis using continuous measures. In exploratory analysis, the association between circulating phospholipid pentadecanoic acid and CVD risk, especially CHD risk, appeared to be nonlinear with a U-shaped curve. Finally, heptadecanoic acid was associated with a higher risk of non-CVD mortality, without a clear concentration of risk for any subtype of non-CVD death. These findings expand on previous studies by using repeated circulating fatty acid measures to estimate long-term exposure and examining associations with total and cause-specific mortality and CVD outcomes in a large, prospective cohort of older adults. Although for decades dairy fat consumption has been hypothesized to be a risk factor for CVD, as well as potentially diabetes, weight gain, and cancer (32–34), little empirical evidence for these effects existed from studies of clinical events. In current years, a growing number of prospective studies have shown generally neutral or protective associations between self-reported dairy foods and dairy fat consumption with the risk of CVD, diabetes, weight gain, and cancers, raising questions about this conventional wisdom (32, 35–40). Dairy fats comprise predominantly SFAs of varying carbon chain lengths with divergent effects on various blood lipids, glucose-insulin homeostasis, and insulin resistance (1, 41), which may partially explain neutral associations. In addition, emerging evidence from randomized controlled trials suggests the differential effects of dairy foods on plasma lipids might be influenced by the presence of milk-fat globule membrane, a tri-layered membrane rich in bioactive phospholipids and proteins enclosing the milk fat (42–44). Consistent with these divergent and complex physiologic effects, our results suggest that overall dairy fat consumption later in life does not significantly influence total mortality but may have associations with specific outcomes. Edited August 28, 2018 by Todd Allen Quote Link to comment Share on other sites More sharing options...
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