ras Posted October 28, 2018 Report Share Posted October 28, 2018 The latest issue of Nature reports that "Genetic and pharmacological inhibition of ACMSD boosts de novo NAD+ synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function." The abstract is available here for non-subscribers. A related complete article by the lead author of the Nature report is available here for download. According to its abstract: "Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan." Link to comment Share on other sites More sharing options...
Todd Allen Posted October 28, 2018 Report Share Posted October 28, 2018 ras, thanks for posting. A link to the full Nature article for non-subscribers: [DELETED: Todd, others: please do not link to sites sidestepping c0pyrigh+ law] Link to comment Share on other sites More sharing options...
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