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Life extension by cocktail?

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Nine healthy subjects who took a three-drug cocktail for a year seem to have reversed their biological ages by 2 1/2 years, as indicated by changes to their epigenetic clocks.

The news write-up in Nature is here.

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I believe we all know tha caution should govern in these cases: taking drugs is very often a trade-off and there are some hazards of unwanted collateral effects. First of all, do we really need HGH, is our IGF-1 so low, are we metabolically healthy or not, and so on. In that study there has not been a control arm. There are probably no doubts that in some subjects that cocktail might be beneficial, the hallmark of ''safe eligibility' to the treatment should be specified though.

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