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Stronger bones from heat and microbiota


corybroo
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Stronger bones thanks to heat and microbiota

 exposure to warmer ambient temperatures (34 °C) increases bone strength, while preventing the loss of bone density typical of osteoporosis. Moreover, this phenomenon, linked to a change in the composition of gut microbiota triggered by heat, could be replicated by transplanting the microbiota of mice living in a warm environment to mice suffering from osteoporosis.

The simple fact of warming the living environment of our mice protected them from the bone loss typical of osteoporosis

The research team analyzed global epidemiological data on the incidence of osteoporosis in relation to the average temperature, latitude, calcium consumption and vitamin D levels. Interestingly, they found that the higher the temperature, the fewer hip fractures—one of the main consequences of osteoporosis— regardless of other factors. 

Normalizing the analysis of the known players such as vitamin D or calcium did not modify this correlation.

they transplanted the microbiota of mice living in a 34° environment to osteoporotic mice, whose bone quality was rapidly improved. 

When [the microbiota] adapts to heat, it leads to a disruption in the synthesis and degradation of polyamines, molecules that are involved in aging, and in particular in bone health.

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