Sibiriak Posted September 13, 2019 Report Share Posted September 13, 2019 (edited) Todd makes some excellent points about the limitations of this study. As he mentioned, there has already been some interesting and detailed discussion on the CR/bone health issue by Dean P., Michael R. and others. I personally don't practice severe CR, so I'm not inclined to spend the time to dig up those posts at the moment, but for those interested in the topic, I suggest they do so. Quote Todd Allen: I wasn't able to get the full paper through scihub but my expectation is variations in diet and exercise could play a big role in the outcome I doubt this single study thoroughly examined all factors. Yes, it's hard to say anything concrete without access to the full paper. I would certainly like to know more about the regular diet (RD) used in the study. Quote There were four groups of mice in all—a group on a regular diet (RD), a group on a calorie-restricted (CR) diet, a RD group that exercised, and a CR group that exercised. Mice in the CR group ate 30 percent less than what RD mice ate. For context in humans, according to the United States Department of Agriculture (USDA), a 'moderately active' woman around the age of 30 should consume 2,000 calories per day. A 30 percent reduction would equal a diet of 1,400 calories per day, which is around the amount suggested to most women trying to lose weight at a rate of one pound a week. https://medicalxpress.com/news/2019-09-restricting-calories-bad-bone-health.html Does that suggest that the CR diet was a very serious weight-loss diet (for six weeks), not necessarily analogous to a long-term, steady-state CR diet? Again, I haven't read the paper, and on top of that, I'm not an expert at all in the design details of CR mouse studies like some of the other posters here are. Edited September 13, 2019 by Sibiriak Quote Link to comment Share on other sites More sharing options...
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