Mike Lustgarten Posted April 25, 2021 Report Share Posted April 25, 2021 (edited) Papers referenced in the video: The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population: https://immunityageing.biomedcentral.... Bioanalytical advances in assays for C-reactive protein: https://pubmed.ncbi.nlm.nih.gov/26717... Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians: https://pubmed.ncbi.nlm.nih.gov/26629... High-sensitivity C-reactive protein predicts mortality but not stroke: https://www.ncbi.nlm.nih.gov/pmc/arti... Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998: https://pubmed.ncbi.nlm.nih.gov/18156... High sensitive C-reactive protein (hsCRP), cardiovascular events and mortality in the aged: a prospective 9-year follow-up study: https://pubmed.ncbi.nlm.nih.gov/25456... Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study: https://pubmed.ncbi.nlm.nih.gov/26823... Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality: https://pubmed.ncbi.nlm.nih.gov/23228... Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort: https://pubmed.ncbi.nlm.nih.gov/32102... C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study: https://pubmed.ncbi.nlm.nih.gov/15821... High-sensitivity C-reactive protein and cystatin C independently and jointly predict all-cause mortality among the middle-aged and elderly Chinese population: https://pubmed.ncbi.nlm.nih.gov/30592... Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study: https://pubmed.ncbi.nlm.nih.gov/23821... High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in a Japanese Population: https://pubmed.ncbi.nlm.nih.gov/27268... Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein: https://pubmed.ncbi.nlm.nih.gov/18227... Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population: https://pubmed.ncbi.nlm.nih.gov/18790... Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality: https://pubmed.ncbi.nlm.nih.gov/29191... High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study: https://pubmed.ncbi.nlm.nih.gov/18403... An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676... DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669... Edited April 25, 2021 by Dean Pomerleau Embedded video Quote Link to comment Share on other sites More sharing options...
Sibiriak Posted April 25, 2021 Report Share Posted April 25, 2021 (edited) Hi Mike, thanks for the video. One observation: Early in the video you state that HS-CRP "measures from 0.2- 10 mg/L". But apparently some labs have detection limits lower than 0.2 mg/L. The lab I use claims a HS-CRP detection lower limit of 0.1 mg/L. (Mine came in recently at 0.2 mg/L) In the video you show the LabCorp refererence range to be 0 - 3.0 mg/L. The graphic from the Laaksonen et al. 2003 paper shows the lowest measurement at 0.1 mg/L. Same for the Ahmadi-Abhari et al. 2013 and Makita et al 2009 papers. The Shinkal et al. 2008 paper shows measurements beginning from 0.03 mg/L. And I know that one of our prolific posters, Ron Put, has stated several times that his CRP has been measured at 0.02 mg/L, which indicates an extraordinarily low detection limit. Interestingly, the Zuo 2016 paper shows a J-shaped curve with the lowest hazard ratio point at around 0.5 mg/L-- not at the lowest measured value. In that study, the lower detection limit was 0.1 mg/L: Quote Plasma high-sensitivity CRP level was determined using an immuno-MALDI [matrix-assisted laser desorption/ionization] mass spectrometry method (26). [...] For CRP, the limit of detection was 0.1 mg/L, and within-day and between-day coefficients of variation were 3.3%–5.5% and 2.4%–7.0%, respectively Edited April 25, 2021 by Sibiriak Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted April 25, 2021 Author Report Share Posted April 25, 2021 (edited) Yes, you're right, thanks Sibiriak. Edited April 25, 2021 by Mike Lustgarten Quote Link to comment Share on other sites More sharing options...
Ron Put Posted April 28, 2021 Report Share Posted April 28, 2021 On 4/25/2021 at 5:36 AM, Sibiriak said: In the video you show the LabCorp refererence range to be 0 - 3.0 mg/L. Yep, mine has been generally done by LabCorp, with two tests by another, smaller lab, that showed <0.05 in 2017 and then the same 0.02 as LabCorp in 2018 (maybe they had upgraded the equipment). They had flagged it as "Low" though. Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted April 28, 2021 Author Report Share Posted April 28, 2021 Based on the published data, as low as possible seems to be best so those values are great, Ron! Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted February 14 Report Share Posted February 14 Quote we present evidence that higher circulating CRP level is unlikely to be an important causal risk factor for CHD. We found no association of a genetic variant (rs1130864) in CRP with CHD events, despite this variant being consistently associated with circulating CRP. Using rs1130864 to explore the causal association of CRP levels with CHD risk is valid since individuals who are homozygous for the T allele (TT genotype) will have experienced on average higher levels of circulating CRP over their lifetime than other individuals (CT or CC genotype),[39] but potential confounding factors will be evenly distributed between these two groups of individuals (TT versus CT or CC), as demonstrated for all our cohorts in table 3. Thus, the association of rs1130864 with CHD cannot be influenced by reverse causality, attenuation by errors or confounding https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003011 also less than 1% of variation explained Quote Link to comment Share on other sites More sharing options...
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