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C-Reactive Protein: What's Optimal? A Comprehensive Review


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Papers referenced in the video:

 

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population: https://immunityageing.biomedcentral....

 

Bioanalytical advances in assays for C-reactive protein: https://pubmed.ncbi.nlm.nih.gov/26717...

 

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians: https://pubmed.ncbi.nlm.nih.gov/26629...

 

High-sensitivity C-reactive protein predicts mortality but not stroke: https://www.ncbi.nlm.nih.gov/pmc/arti...

 

Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998: https://pubmed.ncbi.nlm.nih.gov/18156...

 

High sensitive C-reactive protein (hsCRP), cardiovascular events and mortality in the aged: a prospective 9-year follow-up study: https://pubmed.ncbi.nlm.nih.gov/25456...

 

Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study: https://pubmed.ncbi.nlm.nih.gov/26823...

 

Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality: https://pubmed.ncbi.nlm.nih.gov/23228...

 

Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort: https://pubmed.ncbi.nlm.nih.gov/32102...

 

C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study: https://pubmed.ncbi.nlm.nih.gov/15821...

 

High-sensitivity C-reactive protein and cystatin C independently and jointly predict all-cause mortality among the middle-aged and elderly Chinese population: https://pubmed.ncbi.nlm.nih.gov/30592...

 

Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study: https://pubmed.ncbi.nlm.nih.gov/23821...

 

High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in a Japanese Population: https://pubmed.ncbi.nlm.nih.gov/27268...

 

Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein: https://pubmed.ncbi.nlm.nih.gov/18227...

 

Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population: https://pubmed.ncbi.nlm.nih.gov/18790...

 

Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality: https://pubmed.ncbi.nlm.nih.gov/29191...

 

High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study: https://pubmed.ncbi.nlm.nih.gov/18403...

 

An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676...

 

DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669...

Edited by Dean Pomerleau
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Hi Mike,  thanks for the video.

One observation:  Early in the video you state that HS-CRP "measures from 0.2- 10 mg/L".  

But apparently  some labs have detection limits lower than 0.2 mg/L.

The lab I use claims a  HS-CRP detection lower limit of 0.1 mg/L.  (Mine came in recently at 0.2 mg/L)

In the video you show the LabCorp refererence range to be  0 - 3.0 mg/L.

The graphic from the Laaksonen et al.  2003 paper shows the lowest measurement at  0.1 mg/L.  Same for the Ahmadi-Abhari et al. 2013 and Makita et al 2009  papers.

The Shinkal et al. 2008 paper shows measurements beginning from 0.03 mg/L.

And I know that one of our prolific posters, Ron Put, has stated several times that his CRP has been  measured at 0.02 mg/L,  which indicates an extraordinarily low detection limit.

 

Interestingly, the Zuo 2016 paper  shows a  J-shaped curve with the lowest hazard ratio point at around 0.5 mg/L--  not at the lowest measured value.

image.thumb.png.03dad75430ed854bf19621756c5b7949.png

 

In that study,  the lower detection limit was 0.1 mg/L:

Quote

Plasma high-sensitivity CRP level was determined using an immuno-MALDI [matrix-assisted laser desorption/ionization] mass spectrometry method (26).  [...] For CRP, the limit of detection was 0.1 mg/L, and within-day and between-day coefficients of variation were 3.3%–5.5% and 2.4%–7.0%, respectively

 

 

Edited by Sibiriak
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On 4/25/2021 at 5:36 AM, Sibiriak said:

In the video you show the LabCorp refererence range to be  0 - 3.0 mg/L.

Yep, mine has been generally done by LabCorp, with two tests by another, smaller lab, that showed <0.05 in 2017 and then the same 0.02 as LabCorp in 2018 (maybe they had upgraded the equipment). They had flagged it as "Low" though.

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