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To stay young, kill zombie cells (Nature article/podcast, 24-Oct-2017)

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New article focusing on senescence and senolytics. In the Podcast,  Judy Campisi and Jan van Deursen discuss why they're excited to be researching senescence.

 

https://www.nature.com/news/to-stay-young-kill-zombie-cells-1.22872

 

"Killing off cells that refuse to die on their own has proved a powerful anti-ageing strategy in mice. Now it's about to be tested in humans."
 
Nature 550, 448–450 (26 October 2017) doi:10.1038/550448a

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At what age would one want to think about using senolytics? 

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Whenever the science is perfected.  (You look a bit on the young side for unproven age reversal experiments --- no matter how good the idea seems.)

Wait until age 30 before thinking about it -- and, you might live longer if you just avoid thinking about it, and enjoy life.

😊

  --  Saul

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Cautionary note re drugs that target senescent cells ~

"The idea that we can use natural substances to selectively target cellular senescence has opened a promising new door in the fight against cancer and aging.6

"Studies have used drugs and synthetic biological products capable of clearing away accumulated aging cells in aging tissues. In animals, these compounds have produced dramatic results, such as delaying the onset of aging, slowing existing age-related changes, and even extending lifespans.7-9 But in their current state of development, these drugs and other synthetic products are impractical, dangerous, or both, making them entirely unsuitable for use in humans to prevent either aging or cancer.

"Researchers have found that two natural compounds, when combined, successfully remove aging cells from the body without harmful side effects."

Tocotrienols + Quercetin

- Life Extension Magazine

https://www.lifeextension.com/Magazine/2016/10/Natural-Compounds-that-Remove-Aging-Cells/Page-01

Edited by Dale Hoover

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