ras Posted August 25, 2019 Report Share Posted August 25, 2019 In this blog post, I attempt to describe some recent research in the benefits of dietary restriction and exercise. The blog post is aimed at an educated but largely non-technical audience. Most of the content will be familiar to members of this forum. Nevertheless, comments are invited, because I hope to publish such updates several times a year. Suggestions regarding topics and treatment would be welcome. Quote Link to comment Share on other sites More sharing options...
Saul Posted August 25, 2019 Report Share Posted August 25, 2019 Nice! -- Saul Quote Link to comment Share on other sites More sharing options...
corybroo Posted August 27, 2019 Report Share Posted August 27, 2019 A nice introduction to the variables we can control to best play the genetic hand we've been dealt. To the benefits of exercise, you may want to add the possible modification of telomere length. Do a google search for HIIT telomere length https://www.researchgate.net/publication/325134827_The_effect_of_high_intensity_interval_training_on_telomere_length_and_telomerase_activity_in_non-athlete_young_men Conclusion: It seems that HIIT can alter telomerase activity and telomere length. Therefore, these training may have a positive effect on cell biology. To the section on IF, you may want to add something about preservation vs repair mode in different states. And possibly, as inspiration for others, how you're choosing to bring all this together for your self. As much as anything, that's to avoid the old cartoon of an overweight doctor telling his patient to lose weight. HTH, Cory Quote Link to comment Share on other sites More sharing options...
Sibiriak Posted August 28, 2019 Report Share Posted August 28, 2019 Regarding telomere length modification, Al Pater recently posted this study: Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D. Aging Cell. 2019 Aug 24:e13017. doi: 10.1111/acel.13017. [Epub ahead of print] PMID: 31444995 https://www.crsociety.org/topic/11801-als-papers-citations-and-possibly-links-and-excerpts-or-my-synopses/?page=33&tab=comments#comment-32554 Quote Abstract Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for testing associations with health outcomes, more robust to confounding and reverse causation than observational studies. We tested associations between genetically determined telomere length and aging-related health outcomes in a large European ancestry older cohort. Data were from n = 379,758 UK Biobank participants aged 40-70, followed up for mean of 7.5 years (n = 261,837 participants aged 60 and older by end of follow-up). Thirteen variants strongly associated with longer telomere length in peripheral white blood cells were analyzed using Mendelian randomization methods with Egger plots to assess pleiotropy. Variants in TERC, TERT, NAF1, OBFC1, and RTEL1 were included, and estimates were per 250 base pairs increase in telomere length, approximately equivalent to the average change over a decade in the general white population. We highlighted associations with false discovery rate-adjusted p-values smaller than .05. Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). Little evidence for associations were found with parental lifespan, centenarian status of parents, cognitive function, grip strength, sarcopenia, or falls. The results for those aged 60 and older were similar in younger or all participants. Genetically determined telomere length was associated with increased risk of cancer and reduced risk of CHD but little change in other age-related health outcomes. Telomere lengthening may offer little gain in later-life health status and face increasing cancer risks. Full text here: https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.13017 Quote CONCLUSIONS: In European ancestry 60‐ to 70‐year‐olds followed for 7.5 years, those inheriting more variants linked to longer telomeres were protected from cardiovascular heart disease but did not have bet‐ter healthy aging measures, with no better cognitive function, grip strength, sarcopenia, or falls. The presence of a risk of excess cancer in those with genetically longer telomeres poses a major hurdle in harnessing telomere lengthening to prolong human lifespan. Our findings thus do not suggest advantages in lengthening telomeres to improve human aging outcomes. See also: Telomere length: is the future in our “ends”? (2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064787/ Quote Link to comment Share on other sites More sharing options...
ras Posted September 6, 2019 Author Report Share Posted September 6, 2019 Many thanks to Saul, corybroo, and Sibiriak for their comments. The suggestions of follow-up on HIIT and telomere length will definitely be pursued. But now I'm wondering whether telomere length is really a reliable marker for biological age. If not, what are we to make of the Nature / Aging Cell study I posted in this forum today? Quote Link to comment Share on other sites More sharing options...
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