TomBAvoider Posted September 1, 2020 Report Share Posted September 1, 2020 ...in mice. AKG is in the news again - and dollar signs are dancing in people's eyes: A dietary supplement bodybuilders use to bulk up may have a more sweeping health benefit: Staving off the ravages of old age "Ponce de Leon Health already sells a formulation of AKG called Rejuvant that it says can “slow the aging process.” Kennedy defends these claims. “We are upfront about the data that we have and do not yet have on the website,” he says. And Brown-Borg notes the Buck team isn’t the first group of aging-focused researchers to start a company to develop an antiaging treatment, an idea she hopes will eventually pan out in clinical trials. “It’s an exciting time in the field,” she says." Quote Link to comment Share on other sites More sharing options...
Todd Allen Posted September 2, 2020 Report Share Posted September 2, 2020 (edited) AKG and AAKG are widely available and fairly inexpensive. Rejuvant is just a slow release form of AKG. Hard to imagine much increased value in that as one can buy cheap bulk powder and dose on whatever schedule one believes is optimal. Edited September 3, 2020 by Todd Allen Quote Link to comment Share on other sites More sharing options...
BrianA Posted September 2, 2020 Report Share Posted September 2, 2020 This looks interesting Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13059 Quote Link to comment Share on other sites More sharing options...
corybroo Posted September 2, 2020 Report Share Posted September 2, 2020 A naturally-occurring metabolite ups lifespan and compresses late-life morbidity in mice Middle-aged mice that had the naturally-occurring metabolite alpha-ketaglutarate (AKG) added to their chow had a better "old age." They were healthier as they aged and experienced a dramatically shorter time of disease and disability before they died Previous studies show that blood plasma levels of AKG can drop up to 10-fold as we age.Fasting and exercise, already shown to promote longevity, increase the production of AKG. AKG is not found in the normal diet, making supplementation the only feasible way to restore its levels. Noting that some of the mice did experience moderate lifespan extension (the average was around 12%), measures of healthspan increased more than 40 percent. Even the mice that died early saw improvements in their health, which was really surprising and encouraging." AKG inhibits the breakdown of protein in muscles, making it a popular supplement among athletes. We think suppression of inflammation could be the basis for the extension of lifespan and probably healthspan Asadi said many of the study results were sex specific, with female mice generally faring better than males. Researchers say the consistent longevity effects of AKG in yeast, C. elegans, and now mice, show that the metabolite is affecting an evolutionary conserved aging mechanism which is likely to be translational to humans. A clinical trial of AKG involving 45 to 65 year olds is being planned at the Centre for Healthy Longevity at the National University of Singapore (NUS). Quote Link to comment Share on other sites More sharing options...
AlPater Posted September 3, 2020 Report Share Posted September 3, 2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. PMID: 32877690 Quote Link to comment Share on other sites More sharing options...
BrianA Posted January 18, 2021 Report Share Posted January 18, 2021 α‐ketoglutarate delays age‐related fertility decline in mammals https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13291 https://www.lifespan.io/news/alpha-ketoglutarate-delays-age‐related-fertility-decline/ Quote Link to comment Share on other sites More sharing options...
Clinton Posted January 19, 2021 Report Share Posted January 19, 2021 (edited) 2 hours ago, JohnBrown said: I have one question. What do you think about testosterone cypionate? And I have a one-word response: Gynecomastia Edited January 19, 2021 by Clinton Quote Link to comment Share on other sites More sharing options...
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