corybroo Posted August 16, 2022 Report Share Posted August 16, 2022 This study found health span benefits for moderate calorie restriction in humans. Calorie reduction lowers protein linked to the aging process In a new study, Yale researchers show that moderate calorie restriction in people reduces the production of a protein called SPARC, which then reins in harmful inflammation and improves health in the aged. In the new study, Dixit and his co-authors further analyzed data from a clinical trial funded by the National Institutes of Health. In the trial, known as Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE), some participants reduced their calorie intake by 14% for two years, while others ate as usual; researchers then tracked the long-term health effects. Looking for genetic changes in participants' fat tissue after one and two years, they found that those who consumed fewer calories had reduced amounts of a protein called SPARC—or secreted protein acidic and rich in cysteine—which has been linked to obesity, diabetes, and inflammation. The researchers found that SPARC triggered inflammation by converting anti-inflammatory immune cells called macrophages into a pro-inflammatory state. However, lowering SPARC production by fat cells in mice reduced inflammation, improved metabolism, and extended their health span as they aged. "We now have a better understanding of how SPARC affects inflammation and health span by acting on macrophages," he added. "And it may be a useful target for inducing the health benefits of calorie restriction without having to actually alter calorie intake." Quote Link to comment Share on other sites More sharing options...
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